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丹蔘이 뇌조직출혈 흰쥐의 신경세포 자연사에 미치는 영향

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dc.contributor.author이흥기-
dc.contributor.author김연섭-
dc.date.available2020-02-29T09:42:20Z-
dc.date.created2020-02-12-
dc.date.issued2012-
dc.identifier.issn1229-1765-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17363-
dc.description.abstractObjects : The purpose of this study was to observe the effect of Salviae Miltriorrhiza Radix(SMR) water-extract on intracerebral hemorrhage(ICH) and neuronal apoptosis in the injured areas. Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. The rats were givened oral SMR treatment once a day for three days after the ICH treatment. TUNEL positive cells in the affected regions were performed by TUNEL assay, Bax and Bcl-2 positive cells by immunohistochemistry and the Bax expression by western blotting method. Results : The results are as follow;1. SMR significantly reduced the number of TUNEL positive cells in the peri-hematoma reigions of ICH-induced rats. 2. SMR significantly reduced the number of Bax positive cells in the peri-hematoma regions of ICH-induced rats. 3. SMR did not affect the number of Bcl-2 positive cells in the peri-hematoma regions of ICH-induced rats. 4. SMR significantly reduced the Bax expressions compared with ICH group in hemorrhagic hemisphere of ICH-induced rats. Conclusion : These results suggest that SMR is effective in reducing neuronal apoptosis.-
dc.language한국어-
dc.language.isoko-
dc.publisher대한본초학회-
dc.relation.isPartOf대한본초학회지-
dc.title丹蔘이 뇌조직출혈 흰쥐의 신경세포 자연사에 미치는 영향-
dc.title.alternativeEffects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass2-
dc.identifier.bibliographicCitation대한본초학회지, v.27, no.3, pp.89 - 94-
dc.identifier.kciidART001662320-
dc.citation.endPage94-
dc.citation.startPage89-
dc.citation.title대한본초학회지-
dc.citation.volume27-
dc.citation.number3-
dc.contributor.affiliatedAuthor이흥기-
dc.contributor.affiliatedAuthor김연섭-
dc.subject.keywordAuthorSalvia Miltriorrhiza Radix(SMR)-
dc.subject.keywordAuthorCollagenase-
dc.subject.keywordAuthorTUNEL-
dc.subject.keywordAuthorBax-
dc.subject.keywordAuthorBcl-2-
dc.description.journalRegisteredClasskci-
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College of Korean Medicine (Premedical course of Oriental Medicine)
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