丹蔘이 뇌조직출혈 흰쥐의 신경세포 자연사에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이흥기 | - |
dc.contributor.author | 김연섭 | - |
dc.date.available | 2020-02-29T09:42:20Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1229-1765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17363 | - |
dc.description.abstract | Objects : The purpose of this study was to observe the effect of Salviae Miltriorrhiza Radix(SMR) water-extract on intracerebral hemorrhage(ICH) and neuronal apoptosis in the injured areas. Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. The rats were givened oral SMR treatment once a day for three days after the ICH treatment. TUNEL positive cells in the affected regions were performed by TUNEL assay, Bax and Bcl-2 positive cells by immunohistochemistry and the Bax expression by western blotting method. Results : The results are as follow;1. SMR significantly reduced the number of TUNEL positive cells in the peri-hematoma reigions of ICH-induced rats. 2. SMR significantly reduced the number of Bax positive cells in the peri-hematoma regions of ICH-induced rats. 3. SMR did not affect the number of Bcl-2 positive cells in the peri-hematoma regions of ICH-induced rats. 4. SMR significantly reduced the Bax expressions compared with ICH group in hemorrhagic hemisphere of ICH-induced rats. Conclusion : These results suggest that SMR is effective in reducing neuronal apoptosis. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한본초학회 | - |
dc.relation.isPartOf | 대한본초학회지 | - |
dc.title | 丹蔘이 뇌조직출혈 흰쥐의 신경세포 자연사에 미치는 영향 | - |
dc.title.alternative | Effects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한본초학회지, v.27, no.3, pp.89 - 94 | - |
dc.identifier.kciid | ART001662320 | - |
dc.citation.endPage | 94 | - |
dc.citation.startPage | 89 | - |
dc.citation.title | 대한본초학회지 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 이흥기 | - |
dc.contributor.affiliatedAuthor | 김연섭 | - |
dc.subject.keywordAuthor | Salvia Miltriorrhiza Radix(SMR) | - |
dc.subject.keywordAuthor | Collagenase | - |
dc.subject.keywordAuthor | TUNEL | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | Bcl-2 | - |
dc.description.journalRegisteredClass | kci | - |
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