Effects of Eleutherococcus Extract Mixture on Endochondral Bone Formation in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Donghun | - |
dc.contributor.author | Lee, Sung Hyun | - |
dc.contributor.author | Cho, Namhoon | - |
dc.contributor.author | Kim, Young-Sik | - |
dc.contributor.author | Song, Jungbin | - |
dc.contributor.author | Kim, Hocheol | - |
dc.date.available | 2020-02-27T04:40:39Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-03-01 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1737 | - |
dc.description.abstract | Eleutherococcus extract mixture (EEM) is an herbal mixture of dried stem of Eleutherococcus sessiliflorus and germinated barley, which has been highly effective, in previous screening and among the traditional medicines to tonify innate qi and acquired qi, respectively. In this study, we investigate the effects of EEM on endochondral bone formation. Female adolescent rats were given EEM, growth hormone or vehicle for 10 days. Tetracycline was intraperitoneally injected to light the fluorescent band 72 h before sacrifice to determine endochondral bone formation. In order to evaluate endocrine or paracrine/autocrine mechanisms, expressions of insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), or bone morphogenetic protein 2 (BMP2) were evaluated after EEM administration in liver or growth plate (GP). EEM oral administration significantly increased endochondral bone formation and proliferative and hypertrophic zonal heights of tibial GP. EEM also upregulated hepatic IGF1 and IGFBP3 mRNA expressions, and IGF1 and BMP2 expressions in GP. Taken together, EEM increases endochondral bone formation through stimulating proliferation and hypertrophy with upregulation of hepatic IGF1 and IGFBP3 expressions. Considering immunohistochemical studies, the effect of EEM may be due to increased local IGF1 and BMP2 expression in GP, which may be considered growth hormone (GH)-dependent endocrine and autocrine/paracrine pathways. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | GROWTH-PLATE CHONDROGENESIS | - |
dc.subject | QUALITY-OF-LIFE | - |
dc.subject | SHORT STATURE | - |
dc.subject | HORMONE DEFICIENCY | - |
dc.subject | ADULT HEIGHT | - |
dc.subject | CHILDREN | - |
dc.subject | SENTICOSUS | - |
dc.subject | SECRETION | - |
dc.subject | BARLEY | - |
dc.subject | CHIISANOSIDE | - |
dc.title | Effects of Eleutherococcus Extract Mixture on Endochondral Bone Formation in Rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000462542300252 | - |
dc.identifier.doi | 10.3390/ijms20051253 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.5 | - |
dc.identifier.scopusid | 2-s2.0-85062963463 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 20 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Donghun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Eleutherococcus sessiliflorus | - |
dc.subject.keywordAuthor | germinated barley | - |
dc.subject.keywordAuthor | endochondral bone formation | - |
dc.subject.keywordAuthor | growth plate | - |
dc.subject.keywordAuthor | IGF1 | - |
dc.subject.keywordPlus | GROWTH-PLATE CHONDROGENESIS | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | SHORT STATURE | - |
dc.subject.keywordPlus | HORMONE DEFICIENCY | - |
dc.subject.keywordPlus | ADULT HEIGHT | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | SENTICOSUS | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | BARLEY | - |
dc.subject.keywordPlus | CHIISANOSIDE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.