Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.contributor.author | Lee, Won Yung | - |
dc.contributor.author | Kim, Chang-Eop | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.contributor.author | Kang, Kyo Bin | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T04:40:41Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-03-01 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1742 | - |
dc.description.abstract | Chronic exposure to cisplatin, a potent anticancer drug, causes irreversible kidney damage. In this study, we investigated the protective effect and mechanism of nine lupane- and ceanothane-type triterpenoids isolated from jujube (Ziziphus jujuba Mill., Rhamnaceae) on cisplatin-induced damage to kidney epithelial LLC-PK1 cells via mitogen-activated protein kinase (MAPK) and apoptosis pathways. Cisplatin-induced LLC-PK1 cell death was most significantly reduced following treatment with 3-dehydroxyceanothetric acid 2-methyl ester (3DC2ME). Additionally, apoptotic cell death was significantly reduced. Expression of c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), and p38 was markedly suppressed by 3DC2ME, indicating inhibition of the MAPK pathway. Treatment with 3DC2ME also significantly reduced expression of active caspase-8 and -3, Bcl-2-associated X protein (Bax), and B cell lymphoma 2 (Bcl-2), indicating the inhibition of apoptosis pathways in the kidneys. We also applied the network pharmacological analysis and identified multiple targets of 3DC2ME related to MAPK signaling pathway and apoptosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.subject | FLOW-CYTOMETRIC DETECTION | - |
dc.subject | DNA-DAMAGE RESPONSE | - |
dc.subject | INDUCED NEPHROTOXICITY | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | PHOSPHATIDYLSERINE EXPRESSION | - |
dc.subject | OLEANOLIC ACID | - |
dc.subject | BETULINIC ACID | - |
dc.subject | ACTIVATION | - |
dc.subject | TRITERPENOIDS | - |
dc.subject | CASPASE-3 | - |
dc.title | Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000462662900054 | - |
dc.identifier.doi | 10.3390/molecules24050878 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.24, no.5 | - |
dc.identifier.scopusid | 2-s2.0-85062415043 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 5 | - |
dc.contributor.affiliatedAuthor | Lee, Won Yung | - |
dc.contributor.affiliatedAuthor | Kim, Chang-Eop | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | MAPKs | - |
dc.subject.keywordAuthor | nephrotoxicity | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordPlus | FLOW-CYTOMETRIC DETECTION | - |
dc.subject.keywordPlus | DNA-DAMAGE RESPONSE | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | PHOSPHATIDYLSERINE EXPRESSION | - |
dc.subject.keywordPlus | OLEANOLIC ACID | - |
dc.subject.keywordPlus | BETULINIC ACID | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | TRITERPENOIDS | - |
dc.subject.keywordPlus | CASPASE-3 | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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