Asian Dust Particles Induce TGF-β1 via Reactive Oxygen Species in Bronchial Epithelial Cells
DC Field | Value | Language |
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dc.contributor.author | Kyung, Sunyoung | - |
dc.contributor.author | Yoon, Jin Young | - |
dc.contributor.author | Kim, Yu Jin | - |
dc.contributor.author | Lee, Sang Pyo | - |
dc.contributor.author | Park, Jeong-Woong | - |
dc.contributor.author | Jeong, Sung Hwan | - |
dc.date.available | 2020-02-29T09:44:33Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 1738-3536 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17464 | - |
dc.description.abstract | Background: Asian dust storms can be transported across eastern Asia. In vitro, Asian dust particle-induced inflammation and enhancement of the allergic reaction have been observed. However, the fibrotic effects of Asian dust particles are not clear. Production of transforming growth factor β 1 (TGF-β 1) and fibronectin were investigated in the bronchial epithelial cells after exposure to Asian dust particulate matter (AD-PM10). Methods: During Asian dust storm periods, air samples were collected. The bronchial epithelial cells were exposed to AD-PM10 with and without the antioxidant, N-acetyl-L-cysteine (NAC). Then TGF-β 1 and fibronectin were detected by Western blotting. The reactive oxygen species (ROS) was detected by the measurement of dicholorodihydrofluorescin (DCF), using a FACScan, and visualized by a confocal microscopy. Results: The expression of TGF-β 1, fibronectin and ROS was high after being exposed to AD-PM10, compared to the control. NAC attenuated both TGF-β 1 and fibronectin expression in the AD-PM10-exposed the bronchial epithelial cells. Conclusion: AD-PM10 may have fibrotic potential in the bronchial epithelial cells and the possible mechanism is AD-PM10-induced intracellular ROS. Copyright©2012. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한결핵및호흡기학회 | - |
dc.relation.isPartOf | Tuberculosis and Respiratory Diseases | - |
dc.title | Asian Dust Particles Induce TGF-β1 via Reactive Oxygen Species in Bronchial Epithelial Cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.4046/trd.2012.73.2.84 | - |
dc.identifier.bibliographicCitation | Tuberculosis and Respiratory Diseases, v.73, no.2, pp.84 - 92 | - |
dc.identifier.kciid | ART001691363 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84866510056 | - |
dc.citation.endPage | 92 | - |
dc.citation.startPage | 84 | - |
dc.citation.title | Tuberculosis and Respiratory Diseases | - |
dc.citation.volume | 73 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kyung, Sunyoung | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Yu Jin | - |
dc.contributor.affiliatedAuthor | Lee, Sang Pyo | - |
dc.contributor.affiliatedAuthor | Park, Jeong-Woong | - |
dc.contributor.affiliatedAuthor | Jeong, Sung Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Air pollutants | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Transforming growth factor β | - |
dc.subject.keywordPlus | acetylcysteine | - |
dc.subject.keywordPlus | dichlorodihydrofluorescein | - |
dc.subject.keywordPlus | fibronectin | - |
dc.subject.keywordPlus | reactive oxygen metabolite | - |
dc.subject.keywordPlus | transforming growth factor beta1 | - |
dc.subject.keywordPlus | air sampling | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bronchus mucosa | - |
dc.subject.keywordPlus | confocal microscopy | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | dust | - |
dc.subject.keywordPlus | fluorescence activated cell sorting | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | particulate matter | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | Western blotting | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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