A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia
DC Field | Value | Language |
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dc.contributor.author | Huh, J. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Jung, C.W. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Kim, S.-H. | - |
dc.contributor.author | Kim, Y.-K. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Shin, M.G. | - |
dc.contributor.author | Moon, J.H. | - |
dc.contributor.author | Sohn, S.K. | - |
dc.contributor.author | Kim, S.H. | - |
dc.contributor.author | Lee, W.S. | - |
dc.contributor.author | Won, J.H. | - |
dc.contributor.author | Mun, Y.C. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Park, J. | - |
dc.contributor.author | Min, W.S. | - |
dc.contributor.author | Kim, D.H. | - |
dc.date.available | 2020-02-29T09:44:52Z | - |
dc.date.created | 2020-02-11 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 0361-8609 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17477 | - |
dc.description.abstract | Core binding factor (CBF) AML with the D816 C-KIT gene mutation demonstrate inferior treatment outcomes. However, the remaining cases without the D816 C-KIT mutation imply a requirement of more sophisticated dissection of the patients according to their prognosis. In this study, we analyzed the prognostic value of a single nucleotide polymorphism array (SNP-A) based karyotyping combined with metaphase cytogenetics (MC) to facilitate further stratification of CBF AML patients. A total of 98 CBF AML patients were included and genome-wide Human SNP 6.0 Arrays (Affymetrix) were performed using marrow samples taken at diagnosis. Overall, 40 abnormal lesions were identified in 25 patients (26%). Survival of the patients with the abnormal lesion(s) detected by SNP-A and/or MC was worse than those without lesions in terms of the 2-year overall survival (OS; 57.5% vs. 76.4%, P = 0.028), event-free (EFS; 45.7% vs. 66.2%, P = 0.072), and leukemia-free survival (LFS; 49.0% vs. 77.4%, P = 0.015), specially in the subgroup with inv(16)/t(16;16) (40.9% vs. 80.2% OS, P = 0.040) and in the subgroup without the D816 C-KIT mutation (61.6% vs. 82.7% OS, P = 0.038). Multivariate analysis confirmed the prognostic impact of the abnormal SNP-A and/or MC lesion on EFS (HR 2.011, P = 0.047), and LFS (HR 3.231, P = 0.005) in the overall CBF AML. This study suggests that the combined use of SNP-A with MC in the CBF AML can provide important prognostic value, especially in the inv(16)/t(16;16) subgroup or in the patients without the D816 C-KIT mutation. © 2012 Wiley Periodicals, Inc. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.isPartOf | American Journal of Hematology | - |
dc.title | A genome-wide single-nucleotide polymorphism-array can improve the prognostic stratification of the core binding factor acute myeloid leukemia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000309065700082 | - |
dc.identifier.doi | 10.1002/ajh.23281 | - |
dc.identifier.bibliographicCitation | American Journal of Hematology, v.87, no.10, pp.961 - 968 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84866752027 | - |
dc.citation.endPage | 968 | - |
dc.citation.startPage | 961 | - |
dc.citation.title | American Journal of Hematology | - |
dc.citation.volume | 87 | - |
dc.citation.number | 10 | - |
dc.contributor.affiliatedAuthor | Park, J. | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | core binding factor | - |
dc.subject.keywordPlus | stem cell factor | - |
dc.subject.keywordPlus | acute granulocytic leukemia | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bone marrow | - |
dc.subject.keywordPlus | cancer prognosis | - |
dc.subject.keywordPlus | cancer survival | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytogenetics | - |
dc.subject.keywordPlus | disease free survival | - |
dc.subject.keywordPlus | event free survival | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gene mutation | - |
dc.subject.keywordPlus | genetic association | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | karyotyping | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | metaphase | - |
dc.subject.keywordPlus | overall survival | - |
dc.subject.keywordPlus | predictive value | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | single nucleotide polymorphism | - |
dc.subject.keywordPlus | Acute Disease | - |
dc.subject.keywordPlus | Adolescent | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Antineoplastic Combined Chemotherapy Protocols | - |
dc.subject.keywordPlus | Chromosome Inversion | - |
dc.subject.keywordPlus | Core Binding Factors | - |
dc.subject.keywordPlus | Cytarabine | - |
dc.subject.keywordPlus | Disease-Free Survival | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Genome-Wide Association Study | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Idarubicin | - |
dc.subject.keywordPlus | Kaplan-Meier Estimate | - |
dc.subject.keywordPlus | Karyotyping | - |
dc.subject.keywordPlus | Leukemia, Myeloid | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Neoplasm Proteins | - |
dc.subject.keywordPlus | Polymorphism, Single Nucleotide | - |
dc.subject.keywordPlus | Prognosis | - |
dc.subject.keywordPlus | Proportional Hazards Models | - |
dc.subject.keywordPlus | Proto-Oncogene Proteins c-kit | - |
dc.subject.keywordPlus | Remission Induction | - |
dc.subject.keywordPlus | Translocation, Genetic | - |
dc.subject.keywordPlus | Young Adult | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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