Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice
DC Field | Value | Language |
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dc.contributor.author | Park, Eun Young | - |
dc.contributor.author | Kim, Eung Hwi | - |
dc.contributor.author | Kim, Mi Hwi | - |
dc.contributor.author | Seo, Young Wan | - |
dc.contributor.author | Lee, Jung Im | - |
dc.contributor.author | Jun, Hee Sook | - |
dc.date.available | 2020-02-29T09:46:26Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17539 | - |
dc.description.abstract | Ecklonia cava (E. cava) is a brown alga that has beneficial effects in models of type 1 and type 2 diabetes. However, the effects of E. cava extracts on diet-induced obesity and type 2 diabetes have not been specifically examined. We investigated the effects of E. cava on body weight, fat content, and hyperglycemia in high-fat diet-(HFD) induced obese mice and sought the mechanisms involved. C57BL/6 male mice were fed a HFD (60% fat) diet or normal chow. After 3 weeks, the HFD diet group was given extracts (200 mg/kg) of E. cava harvested from Jeju (CA) or Gijang (G-CA), Korea or PBS by oral intubation for 8 weeks. Body weights were measured weekly. Blood glucose and glucose tolerance were measured at 7 weeks, and fat pad content and mRNA expression of adipogenic genes and inflammatory cytokines were measured after 8 weeks of treatment. G-CA was effective in reducing body weight gain, body fat, and hyperglycemia and improving glucose tolerance as compared with PBS-HFD mice. The mRNA expression of adipogenic genes was increased, and mRNA expression of inflammatory cytokines and macrophage marker gene was decreased in G-CA-treated obese mice. We suggest that G-CA reduces obesity and glucose levels by anti-inflammatory actions and improvement of lipid metabolism. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI PUBLISHING CORPORATION | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.title | Polyphenol-Rich Fraction of Brown Alga Ecklonia cava Collected from Gijang, Korea, Reduces Obesity and Glucose Levels in High-Fat Diet-Induced Obese Mice | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000307571800001 | - |
dc.identifier.doi | 10.1155/2012/418912 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2012 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-84864956273 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2012 | - |
dc.contributor.affiliatedAuthor | Park, Eun Young | - |
dc.contributor.affiliatedAuthor | Kim, Eung Hwi | - |
dc.contributor.affiliatedAuthor | Kim, Mi Hwi | - |
dc.contributor.affiliatedAuthor | Jun, Hee Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | INDUCED CELL-DAMAGE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | BIOLOGICAL-ACTIVITIES | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | LUNG FIBROBLAST | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | ADIPOGENESIS | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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