Conformational changes of fibrinogen in dispersed carbon nanotubes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sung Jean | - |
dc.contributor.author | Khang, Dongwoo | - |
dc.date.available | 2020-02-29T09:47:18Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17562 | - |
dc.description.abstract | The conformational changes of plasma protein structures in response to carbon nanotubes are critical for determining the nanotoxicity and blood coagulation effects of carbon nanotubes. In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Also, elevation of carbon nanotube density can alter the secondary structures (ie, helices and beta sheets) of fibrinogen. Furthermore, fibrinogen that had been in contact with the nanoparticle material demonstrated a different pattern of heat denaturation compared with free fibrinogen as a result of a variation in hydrophilicity and concentration of carbon nanotubes. Considering the importance of interactions between carbon nanotubes and plasma proteins in the drug delivery system, this study elucidated the correlation between nanoscale physiochemical material properties of carbon nanotubes and associated structural changes in fibrinogen. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | SERUM-ALBUMIN | - |
dc.subject | ADSORPTION | - |
dc.subject | PROTEINS | - |
dc.subject | SURFACES | - |
dc.subject | DELIVERY | - |
dc.title | Conformational changes of fibrinogen in dispersed carbon nanotubes | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000307193100001 | - |
dc.identifier.doi | 10.2147/IJN.S33696 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v.7, pp.4325 - 4333 | - |
dc.identifier.scopusid | 2-s2.0-84870341304 | - |
dc.citation.endPage | 4333 | - |
dc.citation.startPage | 4325 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.citation.volume | 7 | - |
dc.contributor.affiliatedAuthor | Park, Sung Jean | - |
dc.contributor.affiliatedAuthor | Khang, Dongwoo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | carbon nanotubes | - |
dc.subject.keywordAuthor | fibrinogen | - |
dc.subject.keywordAuthor | nanotoxicity | - |
dc.subject.keywordAuthor | conformational change | - |
dc.subject.keywordAuthor | denaturation | - |
dc.subject.keywordPlus | CANCER-THERAPY | - |
dc.subject.keywordPlus | SERUM-ALBUMIN | - |
dc.subject.keywordPlus | ADSORPTION | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.