Atorvastatin and Simvastatin, but not Pravastatin, Up-regulate LPS-Induced MMP-9 Expression in Macrophages by Regulating Phosphorylation of ERK and CREB
DC Field | Value | Language |
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dc.contributor.author | Lee, Dong Kun | - |
dc.contributor.author | Park, Eun Ju | - |
dc.contributor.author | Kim, Eun Kyoung | - |
dc.contributor.author | Jin, JunYup | - |
dc.contributor.author | Kim, Jong Soo | - |
dc.contributor.author | Shin, Ik Jae | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Lee, Hookeun | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.date.available | 2020-02-29T09:47:21Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1015-8987 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17564 | - |
dc.description.abstract | Statins suppress expression of pro-inflammatory cytokines in endothelial cells, whereas they enhance it in immune cells. Pro-inflammatory cytokines and lipopolysaccharide (LPS) induce matrix metalloproteinase (MMP)-9 gene expression in macrophages, which has been linked to progress of various inflammatory diseases. The aim of this study was to identify effects of various statins on LPS-induced MMP-9 gene expression in macrophages and microglia. MMP-9 expression was analyzed by real-time PCR or zymography. Effect of statins on activation of signaling pathways was analyzed by time-dependent phosphorylation of signaling molecules. Atorvastatin and simvastatin, but not pravastatin, up-regulated LPS-induced MMP-9 expression in murine RAW 264.7 macrophages and BV2 microglia. The phosphorylation duration of extracellular signal regulated kinases was extended by simvastatin, but not by atorvastatin or pravastatin. The up-regulation of LPS-induced MMP-9 gene expression by the statins was dependent on extracellular calcium ions and mediated by enhancing phosphorylation of cAMP-responsive element binding protein. Geranylgeranyl pyrophosphate, a precursor for cholesterol synthesis, could suppress up-regulation of LPS-mediated MMP-9 gene expression by atorvastatin and simvastatin. Atorvastatin and simvastatin-mediated up-regulation of LPS-induced MMP-9 gene expression in macrophages and microglia in vitro raises an important concern about use of the widely-prescribed statins in certain inflammatory conditions that are mediated by LPS. Copyright (C) 2012 S. Karger AG, Basel | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.relation.isPartOf | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | - |
dc.subject | FACTOR-KAPPA-B | - |
dc.subject | COENZYME-A REDUCTASE | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | ALPHA PRODUCTION | - |
dc.subject | MATRIX-METALLOPROTEINASE-9 | - |
dc.subject | INHIBITORS | - |
dc.subject | STATINS | - |
dc.subject | GENE | - |
dc.subject | CHOLESTEROL | - |
dc.title | Atorvastatin and Simvastatin, but not Pravastatin, Up-regulate LPS-Induced MMP-9 Expression in Macrophages by Regulating Phosphorylation of ERK and CREB | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000307533600001 | - |
dc.identifier.doi | 10.1159/000341433 | - |
dc.identifier.bibliographicCitation | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, v.30, no.3, pp.499 - 511 | - |
dc.identifier.scopusid | 2-s2.0-84863871129 | - |
dc.citation.endPage | 511 | - |
dc.citation.startPage | 499 | - |
dc.citation.title | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee, Hookeun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | &apos | - |
dc.subject.keywordAuthor | CREB | - |
dc.subject.keywordAuthor | ERK | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | MMP-9 | - |
dc.subject.keywordAuthor | Statin | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | COENZYME-A REDUCTASE | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | ALPHA PRODUCTION | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE-9 | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | STATINS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CHOLESTEROL | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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