Attenuation of diabetic kidney injury in DPP4-deficient rats; role of GLP-1 on the suppression of AGE formation by inducing glyoxalase 1
DC Field | Value | Language |
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dc.contributor.author | Sarker, Mithun Kumer | - |
dc.contributor.author | Lee, Jong Han | - |
dc.contributor.author | Lee, Dae Ho | - |
dc.contributor.author | Chun, Kwang-Hoon | - |
dc.contributor.author | Jun, Hee-Sook | - |
dc.date.available | 2020-03-03T06:42:47Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2020-01-15 | - |
dc.identifier.issn | 1945-4589 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17632 | - |
dc.description.abstract | Dipeptidyl peptidase 4 (DPP4) inactivates incretin hormone glucagon-like peptide-1. DPP4 inhibitors may exert beneficial effects on diabetic nephropathy (DN) independently of glycemic control; however, the mechanisms underlying are not fully understood. Here, we investigated the mechanisms of the beneficial effects of DPP4 inhibition on DN using DPP4-deficient (DPP4-def) rats and rat mesangial cells. Blood glucose and HbA1c significantly increased by streptozotocin (STZ) and no differences were between WT-STZ and DPP4-def-STZ. The albumin level in urine decreased significantly and the albumin/creatinine ratio decreased slightly in DPP4-def-STZ. The glomerular volume in DPP4-def-STZ significantly decreased compared with that of WT-STZ. Advanced glycation end products formation, receptor for AGE (RAGE) protein expression, and its downstream inflammatory cytokines and fibrotic factors in kidney tissue, were significantly suppressed in the DPP4-def-STZ compared to the WT-STZ with increasing glyoxalase-1 (GLO-1) expression responsible for the detoxification of methylglyoxal (MGO). In vitro, exendin-4 suppressed MGO-induced AGEs production by enhancing the expression of GLO-1 and nuclear factor-erythroid 2 p45 subunit-related factor 2, resulting in decreasing pro-inflammatory cytokine levels. This effect was abolished by GLO-1 siRNA. Our data suggest that endogenously increased GLP-1 in DPP4-deficient rats contributes to the attenuation of DN partially by regulating AGEs formation via upregulation of GLO-1 expression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.relation.isPartOf | AGING-US | - |
dc.subject | GLYCATION END-PRODUCTS | - |
dc.subject | DIPEPTIDYL PEPTIDASE-4 INHIBITORS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | METHYLGLYOXAL LEVELS | - |
dc.subject | IV INHIBITOR | - |
dc.subject | RENAL INJURY | - |
dc.subject | RECEPTOR | - |
dc.subject | RAGE | - |
dc.subject | MECHANISMS | - |
dc.subject | NEPHROPATHY | - |
dc.title | Attenuation of diabetic kidney injury in DPP4-deficient rats; role of GLP-1 on the suppression of AGE formation by inducing glyoxalase 1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000507233100034 | - |
dc.identifier.doi | 10.18632/aging.102643 | - |
dc.identifier.bibliographicCitation | AGING-US, v.12, no.1, pp.593 - 610 | - |
dc.identifier.scopusid | 2-s2.0-85078574634 | - |
dc.citation.endPage | 610 | - |
dc.citation.startPage | 593 | - |
dc.citation.title | AGING-US | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Sarker, Mithun Kumer | - |
dc.contributor.affiliatedAuthor | Lee, Jong Han | - |
dc.contributor.affiliatedAuthor | Lee, Dae Ho | - |
dc.contributor.affiliatedAuthor | Chun, Kwang-Hoon | - |
dc.contributor.affiliatedAuthor | Jun, Hee-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | diabetic nephropathy | - |
dc.subject.keywordAuthor | dipeptidyl peptidase 4 | - |
dc.subject.keywordAuthor | glucagon-like peptide-1 | - |
dc.subject.keywordAuthor | glyoxalase-1 | - |
dc.subject.keywordAuthor | advanced glycation end products | - |
dc.subject.keywordPlus | GLYCATION END-PRODUCTS | - |
dc.subject.keywordPlus | DIPEPTIDYL PEPTIDASE-4 INHIBITORS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | METHYLGLYOXAL LEVELS | - |
dc.subject.keywordPlus | IV INHIBITOR | - |
dc.subject.keywordPlus | RENAL INJURY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | RAGE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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