Effect of Intravascular Ultrasound-Guided Drug-Eluting Stent Implantation 5-Year Follow-Up of the IVUS-XPL Randomized Trial
DC Field | Value | Language |
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dc.contributor.author | Hong, Sung-lin | - |
dc.contributor.author | Mintz, Gary S. | - |
dc.contributor.author | Ahn, Chul-Min | - |
dc.contributor.author | Kim, Jung-Sun | - |
dc.contributor.author | Kim, Byeong-Keuk | - |
dc.contributor.author | Ko, Young-Guk | - |
dc.contributor.author | Kang, Tae-Soo | - |
dc.contributor.author | Kang, Woong-Chol | - |
dc.contributor.author | Kim, Yong Hoon | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Hong, Bum-Kee | - |
dc.contributor.author | Choi, Donghoon | - |
dc.contributor.author | Kwon, Hyuckmoon | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Hong, Myeong-Ki | - |
dc.date.available | 2020-03-03T06:42:50Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2020-01-13 | - |
dc.identifier.issn | 1936-8798 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17633 | - |
dc.description.abstract | OBJECTIVES The goal of this study was to evaluate whether the beneficial effect of use of intravascular ultrasound (IVUS) is sustained for long-term follow-up. BACKGROUND The use of IVUS promoted favorable 1-year clinical outcome in the IVUS-XPL (Impact of Intravascular Ultrasound Guidance on the Outcomes of Xience Prime Stents in Long Lesions) trial. It is not known, however, whether this effect is sustained for long-term follow-up. METHODS The IVUS-XPL trial randomized 1,400 patients with long coronary lesions (implanted stent length >= 28 mm) to receive IVUS-guided (n = 700) or angiography-guided (n = 700) everolimus-eluting stent implantation. Five-year clinical outcomes were investigated in patients who completed the original trial. The primary outcome was the composite of major adverse cardiac events, including cardiac death, target lesion-related myocardial infarction, or ischemia-driven target lesion revascularization at 5 years, analyzed by intention-to-treat. RESULTS Five-year follow-up was completed in 1,183 patients (85%). Major adverse cardiac events at 5 years occurred in 36 patients (5.6%) receiving IVUS guidance and in 70 patients (10.7%) receiving angiographic guidance (hazard ratio: 0.50; 95% confidence interval: 0.34 to 0.75; p = 0.001). The difference was driven mainly by a lower risk for target lesion revascularization (31 [4.8%] vs. 55 [8.4%]; hazard ratio: 0.54; 95% confidence interval: 0.33 to 0.89; p = 0.007). By landmark analysis, major adverse cardiac events between 1 and 5 years occurred in 17 patients (2.8%) receiving IVUS guidance and in 31 patients (5.2%) receiving angiographic guidance (hazard ratio: 0.53; 95% confidence interval: 0.29 to 0.95; p = 0.031). CONCLUSIONS Compared with angiography-guided stent implantation, IVUS-guided stent implantation resulted in a significantly lower rate of major adverse cardiac events up to 5 years. Sustained 5-year clinical benefits resulted from both within 1 year and from 1 to 5 years post-implantation. (Impact of Intravascular Ultrasound Guidance on the Outcomes of Xience Prime Stents in Long Lesions [IVUS-XPL Study]: Retrospective and Prospective Follow-Up Study; NCT03866486) (c) 2020 by the American College of Cardiology Foundation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.relation.isPartOf | JACC-CARDIOVASCULAR INTERVENTIONS | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | EVEROLIMUS | - |
dc.subject | THROMBOSIS | - |
dc.subject | LESIONS | - |
dc.subject | SAFETY | - |
dc.subject | SORT | - |
dc.title | Effect of Intravascular Ultrasound-Guided Drug-Eluting Stent Implantation 5-Year Follow-Up of the IVUS-XPL Randomized Trial | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000508234300011 | - |
dc.identifier.doi | 10.1016/j.jcin.2019.09.033 | - |
dc.identifier.bibliographicCitation | JACC-CARDIOVASCULAR INTERVENTIONS, v.13, no.1, pp.62 - 71 | - |
dc.identifier.scopusid | 2-s2.0-85076672997 | - |
dc.citation.endPage | 71 | - |
dc.citation.startPage | 62 | - |
dc.citation.title | JACC-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kang, Woong-Chol | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | intravascular ultrasound | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | EVEROLIMUS | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | LESIONS | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | SORT | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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