Anti-Inflammatory Effects of Modified Buyang Huanwu Decoction
DC Field | Value | Language |
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dc.contributor.author | Ryu, Hyang-Hwa | - |
dc.contributor.author | Kang, Jun-Chul | - |
dc.contributor.author | Namgung, Uk | - |
dc.contributor.author | Kim, Song-Yi | - |
dc.contributor.author | Park, Ji-Yeun | - |
dc.date.available | 2020-03-03T06:42:50Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2020-01-13 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17634 | - |
dc.description.abstract | Background/Aims. Buyang Huanwu decoction (BHD) is a traditional Chinese and Korean herbal medicine prescription that has been widely used to treat various diseases including cerebral ischemia, gynecological disease, and neurological disorders. BHD is commonly used as a variable modified combination for synergistic therapeutic effects. However, the mechanism by which modified BHD (mBHD) produces anti-inflammatory effects has not been elucidated yet. The purpose of this study was to develop mBHD with diminished potential side effects and verify its anti-inflammatory effects. Methods. A cytotoxicity assay for BHD was performed using the MTT assay. Following treatment with BHD, mBHD-1, and mBHD-2 in the presence of lipopolysaccharide (LPS), nitric oxide (NO) secretion was detected in cell supernatants using a NO detection kit. The expression of proinflammatory mediators was detected using RT-PCR and western blotting. To verify the mechanism of mBHD, specific inhibitors of JNK (SP600125) or p38 (SB203580) were used for co-treatment with mBHD, and then the changes in NO and nitric oxide synthase (iNOS) were measured. Results. Both mBHD-1 and mBHD-2 showed greater anti-inflammatory effects than BHD. Both mBHD-1 and mBHD-2 inhibited NO secretion and decreased the expression of IL-1 beta, IL-6, TNF-alpha, and iNOS. Treatment with a p38 inhibitor and a JNK inhibitor in mBHD-1- and mBHD-2-treated cells resulted in inhibition of NO and iNOS. Conclusion. We provided the first experimental evidence that mBHD may be a more useful anti-inflammatory than BHD. High concentrations or long-term use of BHD may be harmful to inflammatory status. Therefore, the length of treatment and concentration should be considered depending on the targeted disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.subject | ASTRAGALUS-MEMBRANACEUS | - |
dc.subject | AXONAL REGENERATION | - |
dc.subject | CEREBRAL-ISCHEMIA | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | INFLAMMATION | - |
dc.subject | INJURY | - |
dc.subject | NERVE | - |
dc.subject | INHIBITOR | - |
dc.subject | MEDICINE | - |
dc.title | Anti-Inflammatory Effects of Modified Buyang Huanwu Decoction | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000510039200001 | - |
dc.identifier.doi | 10.1155/2020/6458460 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2020 | - |
dc.identifier.scopusid | 2-s2.0-85078673992 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2020 | - |
dc.contributor.affiliatedAuthor | Kim, Song-Yi | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | ASTRAGALUS-MEMBRANACEUS | - |
dc.subject.keywordPlus | AXONAL REGENERATION | - |
dc.subject.keywordPlus | CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | NERVE | - |
dc.subject.keywordPlus | INHIBITOR | - |
dc.subject.keywordPlus | MEDICINE | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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