Hepatocyte Growth Factor in Blood and Gastric Cancer Risk: A Nested Case-Control Study
DC Field | Value | Language |
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dc.contributor.author | Jang J. | - |
dc.contributor.author | Ma S.H. | - |
dc.contributor.author | Ko K.-P. | - |
dc.contributor.author | Choi B.Y. | - |
dc.contributor.author | Yoo K.-Y. | - |
dc.contributor.author | Park S.K. | - |
dc.date.available | 2020-03-03T06:46:06Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1538-7755 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17768 | - |
dc.description.abstract | BACKGROUND: Potential of hepatocyte growth factor (HGF)-stimulating signaling pathways related to cytotoxin-associated gene A (CagA) to predict gastric cancer development has not been fully investigated. METHODS: We conducted a nested case-control study consisting of 238 gastric cancer cases and 238 matched controls within the Korean Multicenter Cancer Cohort. Plasma HGF concentrations were measured with a human HGF ELISA. Odds ratios (OR) and 95% confidence intervals (CI) for gastric cancer development according to HGF level were calculated using conditional logistic regression model. RESULTS: Sequential elevation of gastric cancer risk according to HGF level increase was observed (OR, 10.99; 95% CI, 4.91-24.62) for highest quartile HGF (≥364 pg/mL) versus lowest quartile HGF (<167 pg/mL). A significantly increased gastric cancer risk associated with high HGF level measured even 6 or more years prior to cancer diagnosis was also found. The group with both high risk of HGF and CagA-related genetic variants was associated with highest gastric cancer risk compared with the group with both low risk of HGF and genetic variants (Pinteraction = 0.05). Model performance using HGF and CagA-related genetic variants to discriminate gastric cancer was fair [area under the curve of receiver operating characteristic (AUC-ROC), 0.71; 95% CI, 0.64-0.78] and significantly higher than that of model not including those biomarkers. CONCLUSIONS: Our results suggest HGF as a potential biomarker to predict gastric cancer development. IMPACT: These findings suggest HGF as a useful biomarker to predict gastric cancer risk. Further research to assess gastric cancer risk based on useful biomarkers, including HGF, may contribute to primary prevention of gastric cancer. ©2019 American Association for Cancer Research. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NLM (Medline) | - |
dc.relation.isPartOf | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | - |
dc.title | Hepatocyte Growth Factor in Blood and Gastric Cancer Risk: A Nested Case-Control Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000521285500024 | - |
dc.identifier.doi | 10.1158/1055-9965.EPI-19-0436 | - |
dc.identifier.bibliographicCitation | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, v.29, no.2, pp.470 - 476 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85079074874 | - |
dc.citation.endPage | 476 | - |
dc.citation.startPage | 470 | - |
dc.citation.title | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Ko K.-P. | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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