Maslinic acid ameliorates inflammation via the downregulation of NF-κB and STAT-1
DC Field | Value | Language |
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dc.contributor.author | Lee W. | - |
dc.contributor.author | Kim J. | - |
dc.contributor.author | Park E.K. | - |
dc.contributor.author | Bae J.-S. | - |
dc.date.available | 2020-03-03T06:46:17Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17774 | - |
dc.description.abstract | Maslinic acid (MA), a natural compound of the triterpenoid group derived from olive, prevents the generation of pro-inflammatory cytokines and oxidative stress. In human umbilical vein endothelial cells (HUVECs) treated with lipopolysaccharide (LPS), we characterized the effects of MA on the regulation of heme oxygenase (HO)-1, cyclooxygenase (COX-)2, and inducible nitric oxide synthase (iNOS). MA was tested in the lung tissues of LPS-treated mice, to determine its effect on levels of iNOS expression and representative inflammatory mediators such as interleukin (IL)-1α and tumor necrosis factor (TNF)-α. We show that MA induced the expression of HO-1, reduced LPS-induced NF-κB-luciferase activity, and inhibited iNOS/NO and COX-2/PGE2, resulting in the downregulation of STAT-1 phosphorylation. Furthermore, our data show that MA induced the nuclear translocation of Nrf2, increased the binding of Nrf2 to ARE, and decreased IL-1α production in LPS-treated HUVECs. The MA-induced reduction in iNOS/NO expression was reversed by RNAi suppression of HO-1. In mice treated with LPS, MA significantly downregulated levels of iNOS in lung tissue and TNF-α in the bronchoalveolar lavage fluid. Taken together, our findings indicate that MA exerts a critical anti-inflammatory effect by modulating iNOS via the downregulation of NF-κB and p-STAT-1. Thus, we propose that MA may be an ideal substance to treat inflammatory diseases. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Antioxidants | - |
dc.title | Maslinic acid ameliorates inflammation via the downregulation of NF-κB and STAT-1 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000519877100016 | - |
dc.identifier.doi | 10.3390/antiox9020106 | - |
dc.identifier.bibliographicCitation | Antioxidants, v.9, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85078843415 | - |
dc.citation.title | Antioxidants | - |
dc.citation.volume | 9 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kim J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Endothelium | - |
dc.subject.keywordAuthor | INOS | - |
dc.subject.keywordAuthor | Maslinic acid | - |
dc.subject.keywordAuthor | P-STAT-1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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