Phytochemicals against TNFα-mediated neuroinflammatory diseases
DC Field | Value | Language |
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dc.contributor.author | Subedi L. | - |
dc.contributor.author | Lee S.E. | - |
dc.contributor.author | Madiha S. | - |
dc.contributor.author | Gaire B.P. | - |
dc.contributor.author | Jin M. | - |
dc.contributor.author | Yumnam S. | - |
dc.contributor.author | Kim S.Y. | - |
dc.date.available | 2020-03-03T06:46:19Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17776 | - |
dc.description.abstract | Tumor necrosis factor-alpha (TNF-α) is a well-known pro-inflammatory cytokine responsible for the modulation of the immune system. TNF-α plays a critical role in almost every type of inflammatory disorder, including central nervous system (CNS) diseases. Although TNF-α is a well-studied component of inflammatory responses, its functioning in diverse cell types is still unclear. TNF-α functions through its two main receptors: tumor necrosis factor receptor 1 and 2 (TNFR1, TNFR2), also known as p55 and p75, respectively. Normally, the functions of soluble TNF-α-induced TNFR1 activation are reported to be pro-inflammatory and apoptotic. While TNF-α mediated TNFR2 activation has a dual role. Several synthetic drugs used as inhibitors of TNF-α for diverse inflammatory diseases possess serious adverse effects, which make patients and researchers turn their focus toward natural medicines, phytochemicals in particular. Phytochemicals targeting TNF-α can significantly improve disease conditions involving TNF-α with fewer side effects. Here, we reviewed known TNF-α inhibitors, as well as lately studied phytochemicals, with a role in inhibiting TNF-α itself, and TNF-α-mediated signaling in inflammatory diseases focusing mainly on CNS disorders. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | International Journal of Molecular Sciences | - |
dc.title | Phytochemicals against TNFα-mediated neuroinflammatory diseases | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000522551601033 | - |
dc.identifier.doi | 10.3390/ijms21030764 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.21, no.3 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85078687805 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 21 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Subedi L. | - |
dc.contributor.affiliatedAuthor | Lee S.E. | - |
dc.contributor.affiliatedAuthor | Gaire B.P. | - |
dc.contributor.affiliatedAuthor | Jin M. | - |
dc.contributor.affiliatedAuthor | Yumnam S. | - |
dc.contributor.affiliatedAuthor | Kim S.Y. | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Neurodegeneration | - |
dc.subject.keywordAuthor | Neuroinflammation | - |
dc.subject.keywordAuthor | Phytochemicals | - |
dc.subject.keywordAuthor | TNF-α | - |
dc.subject.keywordAuthor | TNFR1 | - |
dc.subject.keywordAuthor | TNFR2 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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