Pan-cancer analysis of whole genomes

Campbell P.J.; Getz G.; Korbel J.O.; Stuart J.M.; Jennings J.L.; Stein L.D.; Perry M.D.; Nahal-Bose H.K.; Ouellette B.F.F.; Li C.H.; Rheinbay E.; Nielsen G.P.; Sgroi D.C.; Wu C.-L.; Faquin W.C.; Deshpande V.; Boutros P.C.; Lazar A.J.; Hoadley K.A.; Louis D.N.; Dursi L.J.; Yung C.K.; Bailey M.H.; Saksena G.; Raine K.M.; Buchhalter I.; Kleinheinz K.; Schlesner M.; Zhang J.; Wang W.; Wheeler D.A.; Ding L.; Simpson J.T.; O’Connor B.D.; Yakneen S.; Ellrott K.; Miyoshi N.; Butler A.P.; Royo R.; Shorser S.I.; Vazquez M.; Rausch T.; Tiao G.; Waszak S.M.; Rodriguez-Martin B.; Shringarpure S.; Wu D.-Y.; Demidov G.M.; Delaneau O.; Hayashi S.; Imoto S.; Habermann N.; Segre A.V.; Garrison E.; Cafferkey A.; Alvarez E.G.; Heredia-Genestar J.M.; Muyas F.; Drechsel O.; Bruzos A.L.; Temes J.; Zamora J.; Baez-Ortega A.; Kim H.-L.; Mashl R.J.; Ye K.; DiBiase A.; Huang K.-L.; Letunic I.; McLellan M.D.; Newhouse S.J.; Shmaya T.; Kumar S.; Wedge D.C.; Wright M.H.; Yellapantula V.D.; Gerstein M.; Khurana E.; Marques-Bonet T.; Navarro A.; Bustamante C.D.; Siebert R.; Nakagawa H.; Easton D.F.; Ossowski S.; Tubio J.M.C.; De La Vega F.M.; Estivill X.; Yuen D.; Mihaiescu G.L.; Omberg L.; Ferretti V.; Sabarinathan R.; Pich O.; Gonzalez-Perez A.; Taylor-Weiner A.; Fittall M.W.; Demeulemeester J.; Tarabichi M.; Roberts N.D.; Van Loo P.; Cortés-Ciriano I.; Urban L.; Park P.; Zhu B.; Pitkänen E.; Li Y.; Saini N.; Klimczak L.J.; Weischenfeldt J.; Sidiropoulos N.; Alexandrov L.B.; Rabionet R.; Escaramis G.; Bosio M.; Holik A.Z.; Susak H.; Prasad A.; Erkek S.; Calabrese C.; Raeder B.; Harrington E.; Mayes S.; Turner D.; Juul S.; Roberts S.A.; Song L.; Koster R.; Mirabello L.; Hua X.; Tanskanen T.J.; Tojo M.; Chen J.; Aaltonen L.A.; Rätsch G.; Schwarz R.F.; Butte A.J.; Brazma A.; Chanock S.J.; Chatterjee N.; Stegle O.; Harismendy O.; Bova G.S.; Gordenin D.A.; Haan D.; Sieverling L.; Feuerbach L.; Chalmers D.; Joly Y.; Knoppers B.; Molnár-Gábor F.; Phillips M.; Thorogood A.; Townend D.; Goldman M.; Fonseca N.A.; Xiang Q.; Craft B.; Piñeiro-Yáñez E.; Muñoz A.; Petryszak R.; Füllgrabe A.; Al-Shahrour F.; Keays M.; Haussler D.; Weinstein J.; Huber W.; Valencia A.; Papatheodorou I.; Zhu J.; Fan Y.; Torrents D.; Bieg M.; Chen K.; Chong Z.; Cibulskis K.; Eils R.; Fulton R.S.; Gelpi J.L.; Gonzalez S.; Gut I.G.; Hach F.; Heinold M.; Hu T.; Huang V.; Hutter B.; Jäger N.; Jung J.; Kumar Y.; Lalansingh C.; Leshchiner I.; Livitz D.; Ma E.Z.; Maruvka Y.E.; Milovanovic A.; Nielsen M.M.; Paramasivam N.; Pedersen J.S.; Puiggròs M.; Sahinalp S.C.; Sarrafi I.; Stewart C.; Stobbe M.D.; Wala J.A.; Wang J.; Wendl M.; Werner J.; Wu Z.; Xue H.; Yamaguchi T.N.; Yellapantula V.; Davis-Dusenbery B.N.; Grossman R.L.; Kim Y.; Heinold M.C.; Hinton J.; Jones D.R.; Menzies A.; Stebbings L.; Hess J.M.; Rosenberg M.; Dunford A.J.; Gupta M.; Imielinski M.; Meyerson M.; Beroukhim R.; Reimand J.; Dhingra P.; Favero F.; Dentro S.; Wintersinger J.; Rudneva V.; Park J.W.; Hong E.P.; Heo S.G.; Kahles A.; Lehmann K.-V.; Soulette C.M.; Shiraishi Y.; Liu F.; He Y.; Demircioğlu D.; Davidson N.R.; Greger L.; Li S.; Liu D.; Stark S.G.; Zhang F.; Amin S.B.; Bailey P.; Chateigner A.; Frenkel-Morgenstern M.; Hou Y.; Huska M.R.; Kilpinen H.; Lamaze F.C.; Li C.; Li X.; Li X.; Liu X.; Marin M.G.; Markowski J.; Nandi T.; Ojesina A.I.; Pan-Hammarström Q.; Park P.J.; Pedamallu C.S.; Su H.; Tan P.; Teh B.T.; Wang J.; Xiong H.; Ye C.; Yung C.; Zhang X.; Zheng L.; Zhu S.; Awadalla P.; Creighton C.J.; Wu K.; Yang H.; Göke J.; Zhang Z.; Brooks A.N.; Fittall M.W.; Martincorena I.; Rubio-Perez C.; Juul M.; Schumacher S.; Shapira O.; Tamborero D.; Mularoni L.; Hornshøj H.; Deu-Pons J.; Muiños F.; Bertl J.; Guo Q.; Gonzalez-Perez A.; Xiang Q.; Bazant W.; Barrera E.; Al-Sedairy S.T.; Aretz A.; Bell C.; Betancourt M.; Buchholz C.; Calvo F.; Chomienne C.; Dunn M.; Edmonds S.; Green E.; Gupta S.; Hutter C.M.; Jegalian K.; Jones N.; Lu Y.; Nakagama H.; Nettekoven G.; Planko L.; Scott D.; Shibata T.; Shimizu K.; Stratton M.R.; Yugawa T.; Tortora G.; VijayRaghavan K.; Zenklusen J.C.; Townend D.; Knoppers B.M.; Aminou B.; Bartolome J.; Boroevich K.A.; Boyce R.; Buchanan A.; Byrne N.J.; Chen Z.; Cho S.; Choi W.; Clapham P.; Dow M.T.; Dursi L.J.; Eils J.; Farcas C.; Fayzullaev N.; Flicek P.; Heath A.P.; Hofmann O.; Hong J.H.; Hudson T.J.; Hübschmann D.; Ivkovic S.; Jeon S.-H.; Jiao W.; Kabbe R.; Kahles A.; Kerssemakers J.N.A.; Kim H.; Kim J.; Koscher M.; Koures A.; Kovacevic M.; Lawerenz C.; Liu J.; Mijalkovic S.; Mijalkovic-Lazic A.M.; Miyano S.; Nastic M.; Nicholson J.; Ocana D.; Ohi K.; Ohno-Machado L.; Pihl T.D.; Prinz M.; Radovic P.; Short C.; Sofia H.J.; Spring J.; Struck A.J.; Tijanic N.; Vicente D.; Wang Z.; Williams A.; Woo Y.; Wright A.J.; Yang L.; Hamilton M.P.; Johnson T.A.; Kahraman A.; Kellis M.; Polak P.; Sallari R.; Sinnott-Armstrong N.; von Mering C.; Beltran S.; Gerhard D.S.; Gut M.; Trotta J.-R.; Whalley J.P.; Niu B.; Espiritu S.M.G.; Gao S.; Huang Y.; Lalansingh C.M.; Teague J.W.; Wendl M.C.; Abascal F.; Bader G.D.; Bandopadhayay P.; Barenboim J.; Brunak S.; Carlevaro-Fita J.; Chakravarty D.; Chan C.W.Y.; Choi J.K.; Diamanti K.; Fink J.L.; Frigola J.; Gambacorti-Passerini C.; Garsed D.W.; Haradhvala N.J.; Harmanci A.O.; Helmy M.; Herrmann C.; Hobolth A.; Hodzic E.; Hong C.; Isaev K.; Izarzugaza J.M.G.; Johnson R.; Juul R.I.; Kim J.; Kim J.K.; Jan Komorowski; Lanzós A.; Larsson E.; Lee D.; Li S.; Li X.; Lin Z.; Liu E.M.; Lochovsky L.; Lou S.; Madsen T.; Marchal K.; Martinez-Fundichely A.; McGillivray P.D.; Meyerson W.; Paczkowska M.; Park K.; Park K.; Pons T.; Pulido-Tamayo S.; Reyes-Salazar I.; Reyna M.A.; Rubin M.A.; Salichos L.; Sander C.; Schumacher S.E.; Shackleton M.; Shen C.; Shrestha R.; Shuai S.; Tsunoda T.; Umer H.M.; Uusküla-Reimand L.; Verbeke L.P.C.; Wadelius C.; Wadi L.; Warrell J.; Wu G.; Yu J.; Zhang J.; Zhang X.; Zhang Y.; Zhao Z.; Zou L.; Lawrence M.S.; Raphael B.J.; Bailey P.J.; Craft D.; Goldman M.J.; Aburatani H.; Binder H.; Dinh H.Q.; Heath S.C.; Hoffmann S.; Imbusch C.D.; Kretzmer H.; Laird P.W.; Martin-Subero J.I.; Nagae G.; Shen H.; Wang Q.; Weichenhan D.; Zhou W.; Berman B.P.; Brors B.; Plass C.; Akdemir K.C.; Bowtell D.D.L.; Burns K.H.; Busanovich J.; Chan K.; Dueso-Barroso A.; Edwards P.A.; Etemadmoghadam D.; Haber J.E.; Jones D.T.W.; Ju Y.S.; Kazanov M.D.; Koh Y.; Kumar K.; Lee E.A.; Lee J.J.-K.; Lynch A.G.; Macintyre G.; Markowetz F.; Navarro F.C.P.; Pearson J.V.; Rippe K.; Scully R.; Villasante I.; Waddell N.; Yang L.; Yao X.; Yoon S.-S.; Zhang C.-Z.; Bergstrom E.N.; Boot A.; Covington K.; Fujimoto A.; Huang M.N.; Islam S.M.A.; McPherson J.R.; Morganella S.; Mustonen V.; Ng A.W.T.; Prokopec S.D.; Vázquez-García I.; Wu Y.; Yousif F.; Yu W.; Rozen S.G.; Rudneva V.A.; Shringarpure S.S.; Turner D.J.; Xia T.; Atwal G.; Chang D.K.; Cooke S.L.; Faltas B.M.; Haider S.; Kaiser V.B.; Karlić R.; Kato M.; Kübler K.; Margolin A.; Martin S.; Nik-Zainal S.; P’ng C.; Semple C.A.; Smith J.; Sun R.X.; Thai K.; Wright D.W.; Yuan K.; Biankin A.V.; Garraway L.; Grimmond S.M.; Adams D.J.; Anur P.; Cao S.; Christie E.L.; Cmero M.; Cun Y.; Dawson K.J.; Dentro S.C.; Deshwar A.G.; Donmez N.; Drews R.M.; Gerstung M.; Ha G.; Haase K.; Jerman L.; Ji Y.; Jolly C.; Lee J.; Lee-Six H.; Malikic S.; Mitchell T.J.; Morris Q.D.; Oesper L.; Peifer M.; Peto M.; Rosebrock D.; Rubanova Y.; Salcedo A.; Sengupta S.; Shi R.; Shin S.J.; Spiro O.; Vembu S.; Wintersinger J.A.; Yang T.-P.; Yu K.; Zhu H.; Spellman P.T.; Weinstein J.N.; Chen Y.; Fujita M.; Han L.; Hasegawa T.; Komura M.; Li J.; Mizuno S.; Shimizu E.; Wang Y.; Xu Y.; Yamaguchi R.; Yang F.; Yang Y.; Yoon C.J.; Yuan Y.; Liang H.; Alawi M.; Borozan I.; Brewer D.S.; Cooper C.S.; Desai N.; Grundhoff A.; Iskar M.; Su X.; Zapatka M.; Lichter P.; Alsop K.; Bruxner T.J.C.; Christ A.N.; Cordner S.M.; Cowin P.A.; Drapkin R.; Fereday S.; George J.; Hamilton A.; Holmes O.; Hung J.A.; Kassahn K.S.; Kazakoff S.H.; Kennedy C.J.; Leonard C.R.; Mileshkin L.; Miller D.K.; Arnau G.M.; Mitchell C.; Newell F.; Nones K.; Patch A.-M.; Quinn M.C.; Taylor D.F.; Thorne H.; Traficante N.; Vedururu R.; Waddell N.M.; Waring P.M.; Wood S.; Xu Q.; deFazio A.; Anderson M.J.; Antonello D.; Barbour A.P.; Bassi C.; Bersani S.; Cataldo I.; Chantrill L.A.; Chiew Y.-E.; Chou A.; Cingarlini S.; Cloonan N.; Corbo V.; Davi M.V.; Duthie F.R.; Gill A.J.; Graham J.S.; Harliwong I.; Jamieson N.B.; Johns A.L.; Kench J.G.; Landoni L.; Lawlor R.T.; Mafficini A.; Merrett N.D.; Miotto M.; Musgrove E.A.; Nagrial A.M.; Oien K.A.; Pajic M.; Pinese M.; Robertson A.J.; Rooman I.; Rusev B.C.; Samra J.S.; Scardoni M.; Scarlett C.J.; Scarpa A.; Sereni E.; Sikora K.O.; Simbolo M.; Taschuk M.L.; Toon C.W.; Vicentini C.; Wu J.; Zeps N.; Behren A.; Burke H.; Cebon J.; Dagg R.A.; De Paoli-Iseppi R.; Dutton-Regester K.; Field M.A.; Fitzgerald A.; Hersey P.; Jakrot V.; Johansson P.A.; Kakavand H.; Kefford R.F.; Lau L.M.S.; Long G.V.; Pickett H.A.; Pritchard A.L.; Pupo G.M.; Saw R.P.M.; Schramm S.-J.; Shang C.A.; Shang P.; Spillane A.J.; Stretch J.R.; Tembe V.; Thompson J.F.; Vilain R.E.; Wilmott J.S.; Yang J.Y.; Hayward N.K.; Mann G.J.; Scolyer R.A.; Bartlett J.; Bavi P.; Chadwick D.E.; Chan-Seng-Yue M.; Cleary S.; Connor A.A.; Czajka K.; Denroche R.E.; Dhani N.C.; Eagles J.; Gallinger S.; Grant R.C.; Hedley D.; Hollingsworth M.A.; Jang G.H.; Johns J.; Kalimuthu S.; Liang S.-B.; Lungu I.; Luo X.; Mbabaali F.; McPherson T.A.; Miller J.K.; Moore M.J.; Notta F.; Pasternack D.; Petersen G.M.; Roehrl M.H.A.; Sam M.; Selander I.; Serra S.; Shahabi S.; Thayer S.P.; Timms L.E.; Wilson G.W.; Wilson J.M.; Wouters B.G.; McPherson J.D.; Beck T.A.; Bhandari V.; Collins C.C.; Fleshner N.E.; Fox N.S.; Fraser M.; Heisler L.E.; Lalonde E.; Livingstone J.; Meng A.; Sabelnykova V.Y.; Shiah Y.-J.; Van der Kwast T.; Bristow R.G.; Ding S.; Fan D.; Li L.; Nie Y.; Xiao X.; Xing R.; Yang S.; Yu Y.; Zhou Y.; Banks R.E.; Bourque G.; Brennan P.; Letourneau L.; Riazalhosseini Y.; Scelo G.; Vasudev N.; Viksna J.; Lathrop M.; Tost J.; Ahn S.-M.; Aparicio S.; Arnould L.; Aure M.R.; Bhosle S.G.; Birney E.; Borg A.; Boyault S.; Brinkman A.B.; Brock J.E.; Broeks A.; Børresen-Dale A.-L.; Caldas C.; Chin S.-F.; Davies H.; Desmedt C.; Dirix L.; Dronov S.; Ehinger A.; Eyfjord J.E.; Fatima A.; Foekens J.A.; Futreal P.A.; Garred Ø.; Giri D.D.; Glodzik D.; Grabau D.; Hilmarsdottir H.; Hooijer G.K.; Jacquemier J.; Jang S.J.; Jonasson J.G.; Jonkers J.; Kim H.-Y.; King T.A.; Knappskog S.; Kong G.; Krishnamurthy S.; Lakhani S.R.; Langerød A.; Larsimont D.; Lee H.J.; Lee J.-Y.; Lee M.T.M.; Lingjærde O.C.; MacGrogan G.; Martens J.W.M.; O’Meara S.; Pauporté I.; Pinder S.; Pivot X.; Provenzano E.; Purdie C.A.; Ramakrishna M.; Ramakrishnan K.; Reis-Filho J.; Richardson A.L.; Ringnér M.; Rodriguez J.B.; Rodríguez-González F.G.; Romieu G.; Salgado R.; Sauer T.; Shepherd R.; Sieuwerts A.M.; Simpson P.T.; Smid M.; Sotiriou C.; Span P.N.; Stefánsson Ó.A.; Stenhouse A.; Stunnenberg H.G.; Sweep F.; Tan B.K.T.; Thomas G.; Thompson A.M.; Tommasi S.; Treilleux I.; Tutt A.; Ueno N.T.; Van Laere S.; Van den Eynden G.G.; Vermeulen P.; Viari A.; Vincent-Salomon A.; Wong B.H.; Yates L.; Zou X.; van Deurzen C.H.M.; van de Vijver M.J.; van’t Veer L.; Ammerpohl O.; Aukema S.; Bergmann A.K.; Bernhart S.H.; Borkhardt A.; Borst C.; Burkhardt B.; Claviez A.; Goebler M.E.; Haake A.; Haas S.; Hansmann M.; Hoell J.I.; Hummel M.; Karsch D.; Klapper W.; Kneba M.; Kreuz M.; Kube D.; Küppers R.; Lenze D.; Loeffler M.; López C.; Mantovani-Löffler L.; Möller P.; Ott G.; Radlwimmer B.; Richter J.; Rohde M.; Rosenstiel P.C.; Rosenwald A.; Schilhabel M.B.; Schreiber S.; Stadler P.F.; Staib P.; Stilgenbauer S.; Sungalee S.; Szczepanowski M.; Toprak U.H.; Trümper L.H.P.; Wagener R.; Zenz T.; Hovestadt V.; von Kalle C.; Kool M.; Korshunov A.; Landgraf P.; Lehrach H.; Northcott P.A.; Pfister S.M.; Reifenberger G.; Warnatz H.-J.; Wolf S.; Yaspo M.-L.; Assenov Y.; Gerhauser C.; Minner S.; Schlomm T.; Simon R.; Sauter G.; Sültmann H.; Biswas N.K.; Maitra A.; Majumder P.P.; Sarin R.; Barbi S.; Bonizzato G.; Cantù C.; Dei Tos A.P.; Fassan M.; Grimaldi S.; Luchini C.; Malleo G.; Marchegiani G.; Milella M.; Paiella S.; Pea A.; Pederzoli P.; Ruzzenente A.; Salvia R.; Sperandio N.; Arai Y.; Hama N.; Hiraoka N.; Hosoda F.; Nakamura H.; Ojima H.; Okusaka T.; Totoki Y.; Urushidate T.; Fukayama M.; Ishikawa S.; Katai H.; Katoh H.; Komura D.; Rokutan H.; Saito-Adachi M.; Suzuki A.; Taniguchi H.; Tatsuno K.; Ushiku T.; Yachida S.; Yamamoto S.; Aikata H.; Arihiro K.; Ariizumi S.-I.; Chayama K.; Furuta M.; Gotoh K.; Hayami S.; Hirano S.; Kawakami Y.; Maejima K.; Nakamura T.; Nakano K.; Ohdan H.; Sasaki-Oku A.; Tanaka H.; Ueno M.; Yamamoto M.; Yamaue H.; Choo S.P.; Cutcutache I.; Khuntikeo N.; Ong C.K.; Pairojkul C.; Popescu I.; Ahn K.S.; Aymerich M.; Lopez-Guillermo A.; López-Otín C.; Puente X.S.; Campo E.; Amary F.; Baumhoer D.; Behjati S.; Bjerkehagen B.; Futreal P.A.; Myklebost O.; Pillay N.; Tarpey P.; Tirabosco R.; Zaikova O.; Flanagan A.M.; Boultwood J.; Bowen D.T.; Cazzola M.; Green A.R.; Hellstrom-Lindberg E.; Malcovati L.; Nangalia J.; Papaemmanuil E.; Vyas P.; Ang Y.; Barr H.; Beardsmore D.; Eldridge M.; Gossage J.; Grehan N.; Hanna G.B.; Hayes S.J.; Hupp T.R.; Khoo D.; Lagergren J.; Lovat L.B.; MacRae S.; O’Donovan M.; O’Neill J.R.; Parsons S.L.; Preston S.R.; Puig S.; Roques T.; Sanders G.; Sothi S.; Tavaré S.; Tucker O.; Turkington R.; Underwood T.J.; Welch I.; Fitzgerald R.C.; Berney D.M.; De Bono J.S.; Cahill D.; Camacho N.; Dennis N.M.; Dudderidge T.; Edwards S.E.; Fisher C.; Foster C.S.; Ghori M.; Gill P.; Gnanapragasam V.J.; Gundem G.; Hamdy F.C.; Hawkins S.; Hazell S.; Howat W.; Isaacs W.B.; Karaszi K.; Kay J.D.; Khoo V.; Kote-Jarai Z.; Kremeyer B.; Kumar P.; Lambert A.; Leongamornlert D.A.; Livni N.; Lu Y.-J.; Luxton H.J.; Marsden L.; Massie C.E.; Matthews L.; Mayer E.; McDermott U.; Merson S.; Neal D.E.; Ng A.; Nicol D.; Ogden C.; Rowe E.W.; Shah N.C.; Thomas S.; Thompson A.; Verrill C.; Visakorpi T.; Warren A.Y.; Whitaker H.C.; Zhang H.; van As N.; Eeles R.A.; Abeshouse A.; Agrawal N.; Akbani R.; Al-Ahmadie H.; Albert M.; Aldape K.; Ally A.; Appelbaum E.L.; Armenia J.; Asa S.; Auman J.T.; Balasundaram M.; Balu S.; Barnholtz-Sloan J.; Bathe O.F.; Baylin S.B.; Benz C.; Berchuck A.; Berrios M.; Bigner D.; Birrer M.; Bodenheimer T.; Boice L.; Bootwalla M.S.; Bosenberg M.; Bowlby R.; Boyd J.; Broaddus R.R.; Brock M.; Brooks D.; Bullman S.; Caesar-Johnson S.J.; Carey T.E.; Carlsen R.; Cerfolio R.; Chandan V.S.; Chen H.-W.; Cherniack A.D.; Chien J.; Cho J.; Chuah E.; Cibulskis C.; Cope L.; Cordes M.G.; Curley E.; Czerniak B.; Danilova L.; Davis I.J.; Defreitas T.; Demchok J.A.; Dhalla N.; Dhir R.; Doddapaneni H.V.; El-Naggar A.; Felau I.; Ferguson M.L.; Finocchiaro G.; Fong K.M.; Frazer S.; Friedman W.; Fronick C.C.; Fulton L.A.; Gabriel S.B.; Gao J.; Gehlenborg N.; Gershenwald J.E.; Ghossein R.; Giama N.H.; Gibbs R.A.; Gomez C.; Govindan R.; Hayes D.N.; Hegde A.M.; Heiman D.I.; Heins Z.; Hepperla A.J.; Holbrook A.; Holt R.A.; Hoyle A.P.; Hruban R.H.; Hu J.; Huang M.; Huntsman D.; Huse J.; Iacobuzio-Donahue C.A.; Ittmann M.; Jayaseelan J.C.; Jefferys S.R.; Jones C.D.; Jones S.J.M.; Juhl H.; Kang K.J.; Karlan B.; Kasaian K.; Kebebew E.; Kim H.K.; Korchina V.; Kundra R.; Lai P.H.; Lander E.; Le X.; Lee D.; Levine D.A.; Lewis L.; Ley T.; Li H.I.; Lin P.; Linehan W.M.; Liu F.F.; Lu Y.; Lype L.; Ma Y.; Maglinte D.T.; Mardis E.R.; Marks J.; Marra M.A.; Matthew T.J.; Mayo M.; McCune K.; Meier S.R.; Meng S.; Mieczkowski P.A.; Mikkelsen T.; Miller C.A.; Mills G.B.; Moore R.A.; Morrison C.; Mose L.E.; Moser C.D.; Mungall A.J.; Mungall K.; Mutch D.; Muzny D.M.; Myers J.; Newton Y.; Noble M.S.; O’Donnell P.; O’Neill B.P.; Ochoa A.; Park J.-W.; Parker J.S.; Pass H.; Pastore A.; Pennell N.A.; Perou C.M.; Petrelli N.; Potapova O.; Rader J.S.; Ramalingam S.; Rathmell W.K.; Reuter V.; Reynolds S.M.; Ringel M.; Roach J.; Roberts L.R.; Robertson A.G.; Sadeghi S.; Saller C.; Sanchez-Vega F.; Schadendorf D.; Schein J.E.; Schmidt H.K.; Schultz N.; Seethala R.; Senbabaoglu Y.; Shelton T.; Shi Y.; Shih J.; Shmulevich I.; Shriver C.; Signoretti S.; Simons J.V.; Singer S.; Sipahimalani P.; Skelly T.J.; Smith-McCune K.; Socci N.D.; Soloway M.G.; Sood A.K.; Tam A.; Tan D.; Tarnuzzer R.; Thiessen N.; Thompson R.H.; Thorne L.B.; Tsao M.; Umbricht C.; Van Den Berg D.J.; Van Meir E.G.; Veluvolu U.; Voet D.; Wang L.; Weinberger P.; Weisenberger D.J.; Wigle D.; Wilkerson M.D.; Wilson R.K.; Winterhoff B.; Wiznerowicz M.; Wong T.; Wong W.; Xi L.; Yau C.; Zhang H.; Zhang H.; Zhang J.; The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

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Pan-cancer analysis of whole genomes

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DC Field	Value	Language
dc.contributor.author	Campbell P.J.	-
dc.contributor.author	Getz G.	-
dc.contributor.author	Korbel J.O.	-
dc.contributor.author	Stuart J.M.	-
dc.contributor.author	Jennings J.L.	-
dc.contributor.author	Stein L.D.	-
dc.contributor.author	Perry M.D.	-
dc.contributor.author	Nahal-Bose H.K.	-
dc.contributor.author	Ouellette B.F.F.	-
dc.contributor.author	Li C.H.	-
dc.contributor.author	Rheinbay E.	-
dc.contributor.author	Nielsen G.P.	-
dc.contributor.author	Sgroi D.C.	-
dc.contributor.author	Wu C.-L.	-
dc.contributor.author	Faquin W.C.	-
dc.contributor.author	Deshpande V.	-
dc.contributor.author	Boutros P.C.	-
dc.contributor.author	Lazar A.J.	-
dc.contributor.author	Hoadley K.A.	-
dc.contributor.author	Louis D.N.	-
dc.contributor.author	Dursi L.J.	-
dc.contributor.author	Yung C.K.	-
dc.contributor.author	Bailey M.H.	-
dc.contributor.author	Saksena G.	-
dc.contributor.author	Raine K.M.	-
dc.contributor.author	Buchhalter I.	-
dc.contributor.author	Kleinheinz K.	-
dc.contributor.author	Schlesner M.	-
dc.contributor.author	Zhang J.	-
dc.contributor.author	Wang W.	-
dc.contributor.author	Wheeler D.A.	-
dc.contributor.author	Ding L.	-
dc.contributor.author	Simpson J.T.	-
dc.contributor.author	O’Connor B.D.	-
dc.contributor.author	Yakneen S.	-
dc.contributor.author	Ellrott K.	-
dc.contributor.author	Miyoshi N.	-
dc.contributor.author	Butler A.P.	-
dc.contributor.author	Royo R.	-
dc.contributor.author	Shorser S.I.	-
dc.contributor.author	Vazquez M.	-
dc.contributor.author	Rausch T.	-
dc.contributor.author	Tiao G.	-
dc.contributor.author	Waszak S.M.	-
dc.contributor.author	Rodriguez-Martin B.	-
dc.contributor.author	Shringarpure S.	-
dc.contributor.author	Wu D.-Y.	-
dc.contributor.author	Demidov G.M.	-
dc.contributor.author	Delaneau O.	-
dc.contributor.author	Hayashi S.	-
dc.contributor.author	Imoto S.	-
dc.contributor.author	Habermann N.	-
dc.contributor.author	Segre A.V.	-
dc.contributor.author	Garrison E.	-
dc.contributor.author	Cafferkey A.	-
dc.contributor.author	Alvarez E.G.	-
dc.contributor.author	Heredia-Genestar J.M.	-
dc.contributor.author	Muyas F.	-
dc.contributor.author	Drechsel O.	-
dc.contributor.author	Bruzos A.L.	-
dc.contributor.author	Temes J.	-
dc.contributor.author	Zamora J.	-
dc.contributor.author	Baez-Ortega A.	-
dc.contributor.author	Kim H.-L.	-
dc.contributor.author	Mashl R.J.	-
dc.contributor.author	Ye K.	-
dc.contributor.author	DiBiase A.	-
dc.contributor.author	Huang K.-L.	-
dc.contributor.author	Letunic I.	-
dc.contributor.author	McLellan M.D.	-
dc.contributor.author	Newhouse S.J.	-
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dc.contributor.author	The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium	-
dc.date.available	2020-03-03T06:46:34Z	-
dc.date.created	2020-02-24	-
dc.date.issued	2020-02	-
dc.identifier.issn	0028-0836	-
dc.identifier.uri	https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17782	-
dc.description.abstract	Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18. © 2020, The Author(s).	-
dc.language	영어	-
dc.language.iso	en	-
dc.publisher	Nature Research	-
dc.relation.isPartOf	Nature	-
dc.title	Pan-cancer analysis of whole genomes	-
dc.type	Article	-
dc.type.rims	ART	-
dc.description.journalClass	1	-
dc.identifier.wosid	000529097800007	-
dc.identifier.doi	10.1038/s41586-020-1969-6	-
dc.identifier.bibliographicCitation	Nature, v.578, no.7793, pp.82 - 93	-
dc.description.isOpenAccess	N	-
dc.identifier.scopusid	2-s2.0-85079038817	-
dc.citation.endPage	93	-
dc.citation.startPage	82	-
dc.citation.title	Nature	-
dc.citation.volume	578	-
dc.citation.number	7793	-
dc.contributor.affiliatedAuthor	Ahn S.-M.	-
dc.type.docType	Article	-
dc.description.journalRegisteredClass	scie	-
dc.description.journalRegisteredClass	scopus	-

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