Development of Botulinum Toxin A-Coated Microneedles for Treating Palmar Hyperhidrosis
DC Field | Value | Language |
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dc.contributor.author | Shim, Doo Hee | - |
dc.contributor.author | Thuy Trang Tguyen | - |
dc.contributor.author | Park, Pil-gu | - |
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Park, Byung-Wook | - |
dc.contributor.author | Jeong, Hye-Rin | - |
dc.contributor.author | Kim, Dae-Sung | - |
dc.contributor.author | Joo, Hyun Woo | - |
dc.contributor.author | Choi, Seong-O | - |
dc.contributor.author | Park, Jung-Hwan | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.date.available | 2020-03-03T07:42:12Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1543-8384 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17899 | - |
dc.description.abstract | Hyperhidrosis is a disorder that is characterized by the production of excess amounts of sweat. The botulinum neurotoxin A (BoNT/A) has been used to treat hyperhidrosis through multiple intradermal injections at the site of the condition. However, because of BoNT/A toxicity, it is important to precisely deliver the proper dose of the toxin to the target site. In addition, the use of a conventional hypodermic needle for multiple injections in the palm makes the approach undesirable and painful. Here, we designed a BoNT/A-coated microneedle (BoNT-MN) array and tested its efficacy as a substitute pain free method to treat hyperhidrosis. BoNT-MNs were prepared by coating polylactic acid microneedles with a BoNT/A formulation and were found to successfully penetrate into a thick skin in vitro. The coating formulations were then tested for their stability at 4, 25, and 37 degrees C for 24 h. BoNT-MNs were found to be much more stable than BoNT/A in a liquid state. Additionally, we carried out in vivo experiments by treating the right paws of mice with BoNT-MNs and found that the treatment induced a significant reduction in the sweating response in the mouse foot pad. Thus, BoNT/A treatment using microneedles is beneficial and may be used as a more efficient and less painful approach to treat hyperhidrosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | MOLECULAR PHARMACEUTICS | - |
dc.subject | ULTRASTRUCTURE | - |
dc.subject | FORMULATIONS | - |
dc.subject | DELIVERY | - |
dc.subject | ANATOMY | - |
dc.subject | OPTIONS | - |
dc.title | Development of Botulinum Toxin A-Coated Microneedles for Treating Palmar Hyperhidrosis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000500650500014 | - |
dc.identifier.doi | 10.1021/acs.molpharmaceut.9b00794 | - |
dc.identifier.bibliographicCitation | MOLECULAR PHARMACEUTICS, v.16, no.12, pp.4913 - 4919 | - |
dc.identifier.scopusid | 2-s2.0-85074711797 | - |
dc.citation.endPage | 4919 | - |
dc.citation.startPage | 4913 | - |
dc.citation.title | MOLECULAR PHARMACEUTICS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Thuy Trang Tguyen | - |
dc.contributor.affiliatedAuthor | Jeong, Hye-Rin | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Sung | - |
dc.contributor.affiliatedAuthor | Joo, Hyun Woo | - |
dc.contributor.affiliatedAuthor | Park, Jung-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | microneedles | - |
dc.subject.keywordAuthor | botulinum toxin A | - |
dc.subject.keywordAuthor | hyperhidrosis | - |
dc.subject.keywordPlus | ULTRASTRUCTURE | - |
dc.subject.keywordPlus | FORMULATIONS | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | ANATOMY | - |
dc.subject.keywordPlus | OPTIONS | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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