Protective Effect of Panaxynol Isolated from Panax vietnamensis against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Lee, Jaemin | - |
dc.contributor.author | Vu-Huynh, Kim Long | - |
dc.contributor.author | Thi Hong Van Le | - |
dc.contributor.author | Thi Hong Tuoi | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Park, Jeong Hill | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Minh Duc Nguyen | - |
dc.contributor.author | Yamabe, Noriko | - |
dc.date.available | 2020-03-03T07:43:00Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17933 | - |
dc.description.abstract | Polyacetylenic compounds isolated from Panax species are comprised of non-polar C17 compounds, exhibiting anti-inflammatory, antitumor, and antifungal activities. Panaxynol represents the major component of the essential oils of ginseng. We investigated whether panaxynol isolated from Panax vietnamensis (Vietnamese ginseng, VG) could prevent cisplatin-induced renal damage induced in vitro and in vivo. Cisplatin-induced apoptotic cell death was observed by staining with annexin V conjugated with Alexa Fluor 488, and western blotting evaluated the molecular mechanism. Panaxynol at concentrations above 0.25 mu M prevented cisplatin-induced LLC-PK1 porcine renal proximal tubular cell death. LLC-PK1 cells treated with cisplatin demonstrated an increase in apoptotic cell death, whereas pretreatment with 2 and 4 mu M panaxynol decreased this effect. Cisplatin demonstrated a marked increase in the phosphorylation of c-Jun N-terminal kinase (JNK), P38, and cleaved caspase-3. However, pretreatment with 2 and 4 mu M panaxynol reversed the upregulated phosphorylation of JNK, P38, and the expression of cleaved caspase-3. We confirmed that the protective effect of panaxynol isolated from P. vietnamensis in LLC-PK1 cells was at least partially mediated by reducing the cisplatin-induced apoptotic damage. In the animal study, panaxynol treatment ameliorated body weight loss and blood renal function markers and downregulated the mRNA expression of inflammatory mediators. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | BIOMOLECULES | - |
dc.subject | FERMENTED BLACK GINSENG | - |
dc.subject | INDUCED NEPHROTOXICITY | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | INJURY | - |
dc.subject | GINSENOSIDES | - |
dc.subject | ANTIFUNGAL | - |
dc.subject | MECHANISMS | - |
dc.subject | RD | - |
dc.title | Protective Effect of Panaxynol Isolated from Panax vietnamensis against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000506636800139 | - |
dc.identifier.doi | 10.3390/biom9120890 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES, v.9, no.12 | - |
dc.identifier.scopusid | 2-s2.0-85076951268 | - |
dc.citation.title | BIOMOLECULES | - |
dc.citation.volume | 9 | - |
dc.citation.number | 12 | - |
dc.contributor.affiliatedAuthor | Lee, Dahae | - |
dc.contributor.affiliatedAuthor | Lee, Jaemin | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.contributor.affiliatedAuthor | Yamabe, Noriko | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Panax vietnamensis | - |
dc.subject.keywordAuthor | panaxynol | - |
dc.subject.keywordAuthor | cisplatin-induced renal damage | - |
dc.subject.keywordAuthor | reno-protective activity | - |
dc.subject.keywordAuthor | cytotoxicity | - |
dc.subject.keywordAuthor | MAPKs | - |
dc.subject.keywordAuthor | caspase-3 | - |
dc.subject.keywordPlus | FERMENTED BLACK GINSENG | - |
dc.subject.keywordPlus | INDUCED NEPHROTOXICITY | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | GINSENOSIDES | - |
dc.subject.keywordPlus | ANTIFUNGAL | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | RD | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.