Novel spa and Multi-Locus Sequence Types (MLST) of Staphylococcus Aureus Samples Isolated from Clinical Specimens in Korean
DC Field | Value | Language |
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dc.contributor.author | Mun, Yae Sung | - |
dc.contributor.author | Hwang, You Jin | - |
dc.date.available | 2020-03-03T07:43:07Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 2079-6382 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17935 | - |
dc.description.abstract | Staphylococcus aureus bacteremia is one of the most frequent and severe bacterial infections worldwide. The increased incidence of S. aureus infections with a diverse pattern of S. aureus protein A (spa) types across different geographic regions is a global challenge. This study investigated a novel spa type of methicillin-resistant S. aureus in a clinically isolated specimen. A total of 109 clinical S. aureus samples were subjected to 19 sets of antimicrobial susceptibility testing using the Kirby-Bauer disk diffusion method. Molecular typing was performed with S. aureus protein A (spa) and multi-locus sequence types (MLST) via polymerase chain reaction and sequencing. The methicillin-resistant S. aureus samples in our study accounted for 55.05% (60/109) of the total. A novel spa type was detected in five (5/60) strains. This gh22 isolate was identified in antimicrobial susceptibility tests of 15 kinds of antibiotics. Antibiotic resistance genes included mecA,TEM, aac(6 ')-aph(2"), ermA, and tetM. Eleven S. aureus samples were classified as t2460, t338, t324, t693, five unknown spa types (new spa types), and undefined MLST (novel MLST). We report a high prevalence rate of t2460 methicillin-resistant S. aureus samples in our country. Additionally, novel spagh22, MLST ST4613, and clonal compact CC5-type strains (T1:M1:B1:B1:M1:E1:K1, r26:r17:r34:r34:r17:r13:r16, mlst;1:4:1:4:559:495:10) showing multidrug resistance were identified among S. aureus samples. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIBIOTICS-BASEL | - |
dc.subject | MULTIPLEX PCR ASSAY | - |
dc.subject | METHICILLIN-RESISTANT | - |
dc.subject | COMMUNITY | - |
dc.subject | STRAINS | - |
dc.subject | EPIDEMIOLOGY | - |
dc.subject | HOSPITALS | - |
dc.subject | SPREAD | - |
dc.subject | INFECTION | - |
dc.subject | CLONES | - |
dc.subject | GENES | - |
dc.title | Novel spa and Multi-Locus Sequence Types (MLST) of Staphylococcus Aureus Samples Isolated from Clinical Specimens in Korean | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000506678800047 | - |
dc.identifier.doi | 10.3390/antibiotics8040202 | - |
dc.identifier.bibliographicCitation | ANTIBIOTICS-BASEL, v.8, no.4 | - |
dc.identifier.scopusid | 2-s2.0-85074357788 | - |
dc.citation.title | ANTIBIOTICS-BASEL | - |
dc.citation.volume | 8 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Mun, Yae Sung | - |
dc.contributor.affiliatedAuthor | Hwang, You Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | spa typing | - |
dc.subject.keywordAuthor | spa | - |
dc.subject.keywordAuthor | MLST | - |
dc.subject.keywordAuthor | multidrug-resistance | - |
dc.subject.keywordAuthor | methicillin-resistant Staphylococcus aureus (MRSA) | - |
dc.subject.keywordPlus | MULTIPLEX PCR ASSAY | - |
dc.subject.keywordPlus | METHICILLIN-RESISTANT | - |
dc.subject.keywordPlus | COMMUNITY | - |
dc.subject.keywordPlus | STRAINS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordPlus | HOSPITALS | - |
dc.subject.keywordPlus | SPREAD | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | CLONES | - |
dc.subject.keywordPlus | GENES | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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