Phellinus linteus Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of Fc epsilon RI-Dependent Signaling Pathway In Vitro and In Vivo
DC Field | Value | Language |
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dc.contributor.author | Kwon, Ha-Kyoung | - |
dc.contributor.author | Park, Hye-Jin | - |
dc.date.available | 2020-03-03T07:43:34Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-11-29 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17955 | - |
dc.description.abstract | Phellinus linteus (PL) has been used as a traditional herbal medicine owing to its immune regulatory activity. Previous studies reported that PL grown on germinated brown rice (PBR) exerted immunomodulatory, anticancer, and anti-inflammatory activities. However, role of PBR on type I hypersensitive reactions has not been studied yet. We found that PBR contained more polyphenolic compounds than PL extract. Among fractions, PBR butanol fraction (PBR-BuOH) significantly contained the most amounts of total polyphenolic contents compared with all extracts or fractions. In this study, anti-allergic activity of PBR-BuOH was examined using in vitro and in vivo models of immunoglobulin E/antigen- (IgE/Ag-) stimulated allergy. The inhibitory activity of degranulation was higher in PBR-BuOH (IC50 41.31 +/- 0.14 mu g/mL) than in PL-BuOH (IC50 108.07 +/- 8.98 mu g/mL). We observed that PBR-BuOH suppressed calcium influx and the level of TNF-alpha and IL-4 mRNA expression in a dose-dependent manner. The phosphorylation of Fyn, Gab2, PI3K, Syk, and I kappa B protein is reduced by PBR-BuOH. Oral administration of PBR-BuOH inhibited allergic reactions including the extravasation of Evans blue dye, ear swelling, and infiltration of immune cells in mice with passive cutaneous anaphylaxis (PCA). These findings suggest that PBR-BuOH might be used as a functional food, a health supplement, or a drug for preventing type I hypersensitive allergic disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | HINDAWI LTD | - |
dc.relation.isPartOf | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.subject | MAST-CELL ACTIVATION | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | HYPERSENSITIVITY REACTIONS | - |
dc.subject | ALTERNATIVE MEDICINE | - |
dc.subject | RAW264.7 MACROPHAGES | - |
dc.subject | ERGOSTEROL PEROXIDE | - |
dc.subject | CYTOKINE PRODUCTION | - |
dc.subject | TNF-ALPHA | - |
dc.subject | INFLAMMATION | - |
dc.subject | ANAPHYLAXIS | - |
dc.title | Phellinus linteus Grown on Germinated Brown Rice Inhibits IgE-Mediated Allergic Activity through the Suppression of Fc epsilon RI-Dependent Signaling Pathway In Vitro and In Vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000501754400006 | - |
dc.identifier.doi | 10.1155/2019/1485015 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2019 | - |
dc.identifier.scopusid | 2-s2.0-85076499634 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2019 | - |
dc.contributor.affiliatedAuthor | Kwon, Ha-Kyoung | - |
dc.contributor.affiliatedAuthor | Park, Hye-Jin | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MAST-CELL ACTIVATION | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | HYPERSENSITIVITY REACTIONS | - |
dc.subject.keywordPlus | ALTERNATIVE MEDICINE | - |
dc.subject.keywordPlus | RAW264.7 MACROPHAGES | - |
dc.subject.keywordPlus | ERGOSTEROL PEROXIDE | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | ANAPHYLAXIS | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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