Sensitive electrochemical detection of amyloid beta peptide in human serum using an interdigitated chain-shaped electrode
DC Field | Value | Language |
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dc.contributor.author | Le, Hien T. Ngoc | - |
dc.contributor.author | Park, Jinsoo | - |
dc.contributor.author | Chinnadayyala, Somasekhar R. | - |
dc.contributor.author | Cho, Sungbo | - |
dc.date.available | 2020-03-03T07:44:15Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-11-01 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17979 | - |
dc.description.abstract | In this study, we developed a small size, low cost, highly sensitive electrochemical biosensor with a low limit of detection by immobilizing specific anti-amyloid-beta (a beta) antibody onto a self-assembled monolayer functionalized interdigitated chain-shaped electrode (anti-a beta/EDC-NHS/SAM/ICE). The anti-a beta/EDC-NHS/SAM/ICE specifically detects a beta 1-42 peptide (a peptide 1-42 amino acids long), which is one of main biomarkers of Alzheimer's disease in human serum (HS). Electrochemical impedance spectroscopy (EIS) was used to characterize the impedance change of the anti-a beta/EDC-NHS/SAM/ICE biosensor for a beta 1-42 detection, which provided a wide linear range of detection from 10(-3) -10(3) ng mL(-1), and a low limit of detection of a beta in HS (100 pg mL(-1)) much lower than the limit of detection of CSF a beta 1-42 (similar to 500 pg mL(-1)), and other biosensors. Therefore, the developed biosensor is sensitive enough to be used for the diagnosis of early stage Alzheimer's disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER ADVANCED TECHNOLOGY | - |
dc.relation.isPartOf | BIOSENSORS & BIOELECTRONICS | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | BIOSENSOR | - |
dc.subject | DIAGNOSIS | - |
dc.subject | IMMUNOSENSOR | - |
dc.subject | BIOMARKERS | - |
dc.subject | MILD | - |
dc.title | Sensitive electrochemical detection of amyloid beta peptide in human serum using an interdigitated chain-shaped electrode | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000497249300031 | - |
dc.identifier.doi | 10.1016/j.bios.2019.111694 | - |
dc.identifier.bibliographicCitation | BIOSENSORS & BIOELECTRONICS, v.144 | - |
dc.identifier.scopusid | 2-s2.0-85072252885 | - |
dc.citation.title | BIOSENSORS & BIOELECTRONICS | - |
dc.citation.volume | 144 | - |
dc.contributor.affiliatedAuthor | Le, Hien T. Ngoc | - |
dc.contributor.affiliatedAuthor | Park, Jinsoo | - |
dc.contributor.affiliatedAuthor | Chinnadayyala, Somasekhar R. | - |
dc.contributor.affiliatedAuthor | Cho, Sungbo | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Interdigitated chain-shaped electrode | - |
dc.subject.keywordAuthor | Amyloid-beta 1-42 peptide | - |
dc.subject.keywordAuthor | anti-a beta antibody | - |
dc.subject.keywordAuthor | Self-assembled monolayer | - |
dc.subject.keywordAuthor | Electrochemical biosensor | - |
dc.subject.keywordAuthor | Electrochemical impedance spectroscopy | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | BIOSENSOR | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | IMMUNOSENSOR | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | MILD | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Electrochemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Electrochemistry | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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