Continentalic Acid Rather Than Kaurenoic Acid Is Responsible for the Anti-Arthritic Activity of Manchurian Spikenard In Vitro and In Vivo
DC Field | Value | Language |
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dc.contributor.author | Hong, Riwon | - |
dc.contributor.author | Kim, Kyoung Soo | - |
dc.contributor.author | Choi, Gwang Muk | - |
dc.contributor.author | Yeom, Mijung | - |
dc.contributor.author | Lee, Bombi | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Lee, Hyang Sook | - |
dc.contributor.author | Park, Hi-Joon | - |
dc.contributor.author | Hahm, Dae-Hyun | - |
dc.date.available | 2020-03-03T07:44:44Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/17998 | - |
dc.description.abstract | The aim of this study was to identify the active compound responsible for the pharmacological activities of Manchurian spikenard (Aralia continentalis Kitag.). Interleukin (IL)-1 beta -stimulated human chondrocytes and monoiodoacetate (MIA)-induced osteoarthritic rats were treated with the 50% ethanolic extract of spikenard or its major components, such as continentalic acid (ent-pimara-8(14),15-diene-19-oic acid) and kaurenoic acid (ent-kaura-16-en-19-oic acid). The spikenard extract significantly inhibited IL-1 beta -stimulated production of IL-6, IL-8, metalloproteinase (MMP)-1, MMP-13, cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and prostaglandin(PG)E2 in a dose-dependent manner but not MMP-3 production. The extract also inhibited the IL-1 beta -induced translocation of NF-kappa B/p65 into the nucleus and dose-dependent phosphorylation levels of extracellular signal-regulated kinase (ERK), Jun amino-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase. Continentalic acid exhibited significant anti-arthritic activity corresponding exactly to that of the extract containing an equivalent amount of continentalic acid. On the other hand, kaurenoic acid exhibited a compatible activity at about a 10-times higher molar concentration than that of continentalic acid. In vitro anti-arthritic activities of the spikenard extract and continentalic acid were also confirmed in MIA-induced osteoarthritic rats. The 50% ethanolic extract of Manchurian spikenard exhibited promising anti-arthritic activities in the in vitro and in vivo osteoarthritis models, and continentalic acid, not kaurenoic acid, was most probably responsible for those activities. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | ARALIA-CORDATA EXTRACTS | - |
dc.subject | ENT-KAUR-16-EN-19-OIC ACID | - |
dc.subject | CARTILAGE PROTECTION | - |
dc.subject | ARTICULAR-CARTILAGE | - |
dc.subject | MMP-13 | - |
dc.subject | INFLAMMATION | - |
dc.subject | IODOACETATE | - |
dc.subject | EXPRESSION | - |
dc.subject | APOPTOSIS | - |
dc.subject | ARTHRITIS | - |
dc.title | Continentalic Acid Rather Than Kaurenoic Acid Is Responsible for the Anti-Arthritic Activity of Manchurian Spikenard In Vitro and In Vivo | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000498946100246 | - |
dc.identifier.doi | 10.3390/ijms20215488 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.21 | - |
dc.identifier.scopusid | 2-s2.0-85074741757 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 20 | - |
dc.citation.number | 21 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | continentalic acid | - |
dc.subject.keywordAuthor | Manchurian spikenard | - |
dc.subject.keywordAuthor | osteoarthritis | - |
dc.subject.keywordAuthor | chondrocyte | - |
dc.subject.keywordAuthor | monoiodoacetate | - |
dc.subject.keywordPlus | ARALIA-CORDATA EXTRACTS | - |
dc.subject.keywordPlus | ENT-KAUR-16-EN-19-OIC ACID | - |
dc.subject.keywordPlus | CARTILAGE PROTECTION | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE | - |
dc.subject.keywordPlus | MMP-13 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | IODOACETATE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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