Hybrid Polyketides from a Hydractinia-Associated Cladosporium sphaerospermum SW67 and Their Putative Biosynthetic Origin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Lee, Dahae | - |
dc.contributor.author | Eom, Hee Jeong | - |
dc.contributor.author | Rischer, Maja | - |
dc.contributor.author | Ko, Yoon-Joo | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Beemelmanns, Christine | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.available | 2020-03-03T07:45:10Z | - |
dc.date.created | 2020-02-24 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/18011 | - |
dc.description.abstract | Five hybrid polyketides (1a, 1b, and 2-4) containing tetramic acid core including a new hybrid polyketide, cladosin L (1), were isolated from the marine fungus Cladosporium sphaerospermum SW67, which was isolated from the marine hydroid polyp of Hydractinia echinata. The hybrid polyketides were isolated as a pair of interconverting geometric isomers. The structure of 1 was determined based on 1D and 2D NMR spectroscopic and HR-ESIMS analyses. Its absolute configuration was established by quantum chemical electronic circular dichroism (ECD) calculations and modified Mosher's method. Tetramic acid-containing compounds are reported to be derived from a hybrid PKS-NRPS, which was also proved by analyzing our C-13-labeling data. We investigated whether compounds 1-4 could prevent cell damage induced by cisplatin, a platinum-based anticancer drug, in LLC-PK1 cells. Co-treatment with 2 and 3 ameliorated the damage of LLC-PK1 cells induced by 25 mu M of cisplatin. In particular, the effect of compound 2 at 100 mu M (cell viability, 90.68 +/- 0.81%) was similar to the recovered cell viability of 88.23 +/- 0.25% with 500 mu M N-acetylcysteine (NAC), a positive control. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MARINE DRUGS | - |
dc.subject | MARINE-DERIVED FUNGUS | - |
dc.subject | NATURAL-PRODUCTS | - |
dc.subject | TETRAMIC ACID | - |
dc.subject | METABOLITES | - |
dc.subject | NEPHROTOXICITY | - |
dc.subject | DIVERSITY | - |
dc.subject | DISCOVERY | - |
dc.subject | PATHWAYS | - |
dc.subject | TENELLIN | - |
dc.title | Hybrid Polyketides from a Hydractinia-Associated Cladosporium sphaerospermum SW67 and Their Putative Biosynthetic Origin | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000502262200048 | - |
dc.identifier.doi | 10.3390/md17110606 | - |
dc.identifier.bibliographicCitation | MARINE DRUGS, v.17, no.11 | - |
dc.identifier.scopusid | 2-s2.0-85074142467 | - |
dc.citation.title | MARINE DRUGS | - |
dc.citation.volume | 17 | - |
dc.citation.number | 11 | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | hybrid polyketides | - |
dc.subject.keywordAuthor | tetramic acid | - |
dc.subject.keywordAuthor | Cladosporium sphaerospermum | - |
dc.subject.keywordAuthor | hybrid PKS-NRPS | - |
dc.subject.keywordAuthor | LLC-PK1 cells | - |
dc.subject.keywordPlus | MARINE-DERIVED FUNGUS | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | TETRAMIC ACID | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | NEPHROTOXICITY | - |
dc.subject.keywordPlus | DIVERSITY | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | TENELLIN | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.