Covalent immobilization of fibroblast-derived matrix on metallic stent for expeditious re-endothelialization
- Authors
- Bedair, Tarek M.; Min, Ii Jae; Park, Wooram; Park, Bang Ju; Joung, Yoon Ki; Han, Dong Keun
- Issue Date
- 25-Feb-2019
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Cardiovascular stent; Fibroblast-derived extracellular matrix (FDM); Endothelial progenitor cells (EPCs); Endothelial cells (ECs); Re-endothelialization
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.70, pp.385 - 393
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 70
- Start Page
- 385
- End Page
- 393
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1826
- DOI
- 10.1016/j.jiec.2018.11.001
- ISSN
- 1226-086X
- Abstract
- Here, we demonstrate a fibroblast-derived extracellular matrix (FDM) immobilized cobalt-chromium (Co-Cr) alloy surface to accelerate re-endothelialization. The surface characterization results showed that FDM molecules with their protein components such as collagen I, fibronectin, and laminin, were covalently grafted to Co-Cr surface. The in vitro cells experiments exhibited the superiority of the FDM-immobilized surface to capture and proliferate of endothelial progenitor and human umbilical cord vein endothelial cells than control Co-Cr alloy. These results suggested that the immobilization of FDM on the stent surface by this facile procedure could be an efficient and promising strategy to get expeditious re-endothelialization. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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