Detailed Information
Cited 5 time in 
Cited 0 time in 
Cited 0 time in
Metadata Downloads
Mitoxantrone-Loaded PEGylated Gold Nanocomplexes for Cancer Therapy
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yoon, Jin-Ha | - |
| dc.contributor.author | Cho, Hyun-Jong | - |
| dc.contributor.author | Jin, Hyo-Eon | - |
| dc.contributor.author | Maeng, Han-Joo | - |
| dc.date.available | 2020-02-27T04:41:44Z | - |
| dc.date.created | 2020-02-05 | - |
| dc.date.issued | 2019-02 | - |
| dc.identifier.issn | 1533-4880 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1866 | - |
| dc.description.abstract | Gold nanoparticles (AuNPs) have been widely used as drug delivery carriers for cancer targeting and therapy. In this study, we developed mitoxantrone (MX)-loaded poly(ethylene glycol)-modified AuNPs complexes (AuNPs-PEG-MX) and evaluated its physicochemical properties compared to AuNPs, free MX, and MX-loaded AuNPs (AuNPs-MX). The results of surface plasmon resonance (SPR) measurement provided corresponded characteristics of free MX and AuNP groups, which determined by electrophoretic light scattering (ELS) method. The hydrodynamic size of AuNPsPEG-MX was lower than that of AuNPs-MX. Furthermore, loading efficiency of AuNPs-PEG-MX was 1.9-fold increased than AuNPs-MX. In addition, AuNPs-PEG-MX showed similar cytotoxicity compared to AuNPs-MX group in HeLa cells with enhanced drug release. Conclusively, AuNPsPEG-MX could be applied for in vivo cancer therapy via passive targeting based on the enhanced permeability and retention effect after intravenous injection. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | AMER SCIENTIFIC PUBLISHERS | - |
| dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
| dc.title | Mitoxantrone-Loaded PEGylated Gold Nanocomplexes for Cancer Therapy | - |
| dc.type | Article | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.identifier.wosid | 000448031900012 | - |
| dc.identifier.doi | 10.1166/jnn.2019.15902 | - |
| dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, v.19, no.2, pp.687 - 690 | - |
| dc.citation.endPage | 690 | - |
| dc.citation.startPage | 687 | - |
| dc.citation.title | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
| dc.citation.volume | 19 | - |
| dc.citation.number | 2 | - |
| dc.contributor.affiliatedAuthor | Yoon, Jin-Ha | - |
| dc.contributor.affiliatedAuthor | Maeng, Han-Joo | - |
| dc.type.docType | Article | - |
| dc.subject.keywordAuthor | Mitoxantrone | - |
| dc.subject.keywordAuthor | Gold Nanoparticle | - |
| dc.subject.keywordAuthor | Polyethylene Glycol | - |
| dc.subject.keywordAuthor | Stability | - |
| dc.subject.keywordAuthor | Loading Efficiency | - |
| dc.subject.keywordPlus | DELIVERY | - |
| dc.subject.keywordPlus | NANOPARTICLES | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
| dc.relation.journalResearchArea | Materials Science | - |
| dc.relation.journalResearchArea | Physics | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
| dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
| dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
| dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
| dc.description.journalRegisteredClass | scie | - |
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Maeng, Han Joo
- Pharmacy (Dept.of Pharmacy)