Enantioselective synthesis and absolute configuration determination of hydroxywilfordic acid in sesquiterpene pyridine alkaloids
DC Field | Value | Language |
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dc.contributor.author | Yuan, Yue | - |
dc.contributor.author | Jung, Jong-Wha | - |
dc.contributor.author | Seo, Seung-Yong | - |
dc.date.available | 2020-02-27T04:42:24Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-01-07 | - |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1953 | - |
dc.description.abstract | An enantioselective synthetic route to hydroxywilfordic acid, a key subunit of sesquiterpene pyridine alkaloids such as wilfortrine, was developed. Asymmetric cyanation using Jacobsen's (R,R)-amino-thiourea and hydrolysis were performed to afford chiral -hydroxy--methyl acid as the (S)-isomer. Naturally derived hydroxywilfordate prepared by methanolysis of wilfortrine was found to be the (R)-isomer upon comparison with the synthetic compound. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.subject | CATALYTIC ASYMMETRIC CYANOSILYLATION | - |
dc.subject | KETONES | - |
dc.title | Enantioselective synthesis and absolute configuration determination of hydroxywilfordic acid in sesquiterpene pyridine alkaloids | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000454251100004 | - |
dc.identifier.doi | 10.1039/c8ob02364f | - |
dc.identifier.bibliographicCitation | ORGANIC & BIOMOLECULAR CHEMISTRY, v.17, no.1, pp.44 - 48 | - |
dc.identifier.scopusid | 2-s2.0-85058839937 | - |
dc.citation.endPage | 48 | - |
dc.citation.startPage | 44 | - |
dc.citation.title | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Yuan, Yue | - |
dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CATALYTIC ASYMMETRIC CYANOSILYLATION | - |
dc.subject.keywordPlus | KETONES | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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