Detailed Information
Cited 10 time in 
Cited 12 time in 
Cited 12 time in
Metadata Downloads
Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Yuan, Yue | - |
| dc.contributor.author | Subedi, Lalita | - |
| dc.contributor.author | Lim, Daesung | - |
| dc.contributor.author | Jung, Jae-Kyung | - |
| dc.contributor.author | Kim, Sun Yeou | - |
| dc.contributor.author | Seo, Seung-Yong | - |
| dc.date.available | 2020-02-27T04:42:37Z | - |
| dc.date.created | 2020-02-05 | - |
| dc.date.issued | 2019-01-15 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1979 | - |
| dc.description.abstract | Novel isoxazole and pyrazole analogs based on natural biphenyl-neolignan honokiol were synthesized and evaluated for their inhibitory activities against nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells. The isoxazole skeleton was constructed via nitrile oxide cycloaddition from oxime 3 and pyrazole was generated by condensation of 4-chromone and alkylhydrazine. Among the analogs, 13b and 14a showed stronger inhibitory activities with IC50 values of 8.9 and 1.2 mu M, respectively, than honokiol. | - |
| dc.language | 영어 | - |
| dc.language.iso | en | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.subject | THERAPEUTIC TARGET | - |
| dc.subject | 4-O-METHYLHONOKIOL | - |
| dc.subject | INFLAMMATION | - |
| dc.subject | MICROGLIA | - |
| dc.subject | MAGNOLOL | - |
| dc.subject | DESIGN | - |
| dc.title | Synthesis and anti-neuroinflammatory activity of N-heterocyclic analogs based on natural biphenyl-neolignan honokiol | - |
| dc.type | Article | - |
| dc.type.rims | ART | - |
| dc.description.journalClass | 1 | - |
| dc.identifier.wosid | 000454616600040 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2018.11.014 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.29, no.2, pp.329 - 333 | - |
| dc.identifier.scopusid | 2-s2.0-85056857049 | - |
| dc.citation.endPage | 333 | - |
| dc.citation.startPage | 329 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 29 | - |
| dc.citation.number | 2 | - |
| dc.contributor.affiliatedAuthor | Yuan, Yue | - |
| dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
| dc.contributor.affiliatedAuthor | Lim, Daesung | - |
| dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
| dc.contributor.affiliatedAuthor | Seo, Seung-Yong | - |
| dc.type.docType | Article | - |
| dc.subject.keywordAuthor | Honokiol | - |
| dc.subject.keywordAuthor | Biphenyl-neolignan | - |
| dc.subject.keywordAuthor | Isoxazole | - |
| dc.subject.keywordAuthor | Pyrazole | - |
| dc.subject.keywordAuthor | Anti-neuroinflammatory activity | - |
| dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
| dc.subject.keywordPlus | 4-O-METHYLHONOKIOL | - |
| dc.subject.keywordPlus | INFLAMMATION | - |
| dc.subject.keywordPlus | MICROGLIA | - |
| dc.subject.keywordPlus | MAGNOLOL | - |
| dc.subject.keywordPlus | DESIGN | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Seo, Seung Yong
- Pharmacy (Dept.of Pharmacy)