Sanguiin H-11 from Sanguisorbae radix protects HT22 murine hippocampal cells against glutamate-induced death
DC Field | Value | Language |
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dc.contributor.author | Song, Ji Hoon | - |
dc.contributor.author | Kim, Song-Yi | - |
dc.contributor.author | Hwang, Gwi Seo | - |
dc.contributor.author | Kim, Youn-Sub | - |
dc.contributor.author | Kim, Hyun Young | - |
dc.contributor.author | Kang, Ki Sung | - |
dc.date.available | 2020-02-27T04:42:38Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-01-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1980 | - |
dc.description.abstract | Excessive glutamate level induces neuronal death in acute brain injuries and chronic neurodegenerative diseases. Natural compounds from medicinal and food plants have been attracting interest as a treatment for neurological disorders. Sanguiin H-11 (SH-11), a hydrolysable ellagitannin, inhibits neutrophil movement and nitric oxide-production. However, its neuroprotective effect has not been studied. Therefore, the present study examined the protective effect of SH-11 from Sanguisorbae radix and its mechanism against glutamate-induced death in HT22 cells. Our results showed that SH-11 possessed a strong antioxidant activity and prevented glutamate-induced death in HT22 cells. As a strong antioxidant, SH-11 significantly reduced glutamate-induced increases in intracellular reactive oxygen species accumulation and calcium ion influx. Western blotting analysis showed that glutamate-induced phosphorylation of mitogen-activated protein kinases (MAPKs), including extracellular signal-related kinases 1/2, c-Jun N-terminal kinase, and p38, was significantly decreased by SH-11. Furthermore, SH-11 significantly decreased the number of annexin V-positive HT22 cells, which is indicating apoptotic cell death. In conclusion, our results suggested that SH-11 exerted a potent neuroprotective activity against glutamate-mediated apoptotic cell death by inhibiting oxidative stress-mediated MAPK activation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | N-ACETYLCYSTEINE | - |
dc.subject | INHIBITION | - |
dc.subject | TOXICITY | - |
dc.subject | ELLAGITANNINS | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | LINE | - |
dc.title | Sanguiin H-11 from Sanguisorbae radix protects HT22 murine hippocampal cells against glutamate-induced death | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000454616600025 | - |
dc.identifier.doi | 10.1016/j.bmcl.2018.11.042 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.29, no.2, pp.252 - 256 | - |
dc.identifier.scopusid | 2-s2.0-85057237170 | - |
dc.citation.endPage | 256 | - |
dc.citation.startPage | 252 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Song, Ji Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Song-Yi | - |
dc.contributor.affiliatedAuthor | Hwang, Gwi Seo | - |
dc.contributor.affiliatedAuthor | Kim, Youn-Sub | - |
dc.contributor.affiliatedAuthor | Kang, Ki Sung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Sanguiin H-11 (SH-11) | - |
dc.subject.keywordAuthor | Glutamate | - |
dc.subject.keywordAuthor | Mitogen-activated protein kinase | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | HT22 cells | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | N-ACETYLCYSTEINE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | ELLAGITANNINS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | LINE | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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