Proteogenomic Characterization of Human Early-Onset Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | Mun, Dong-Gi | - |
dc.contributor.author | Bhin, Jinhyuk | - |
dc.contributor.author | Kim, Sangok | - |
dc.contributor.author | Kim, Hyunwoo | - |
dc.contributor.author | Jung, Jae Hun | - |
dc.contributor.author | Jung, Yeonjoo | - |
dc.contributor.author | Jang, Ye Eun | - |
dc.contributor.author | Park, Jong Moon | - |
dc.contributor.author | Kim, Hokeun | - |
dc.contributor.author | Jung, Yeonhwa | - |
dc.contributor.author | Lee, Hangyeore | - |
dc.contributor.author | Bae, Jingi | - |
dc.contributor.author | Back, Seunghoon | - |
dc.contributor.author | Kim, Su-Jin | - |
dc.contributor.author | Kim, Jieun | - |
dc.contributor.author | Park, Heejin | - |
dc.contributor.author | Li, Honglan | - |
dc.contributor.author | Hwang, Kyu-Baek | - |
dc.contributor.author | Park, Young Soo | - |
dc.contributor.author | Yook, Jeong Hwan | - |
dc.contributor.author | Kim, Byung Sik | - |
dc.contributor.author | Kwon, Sun Young | - |
dc.contributor.author | Ryu, Seung Wan | - |
dc.contributor.author | Park, Do Youn | - |
dc.contributor.author | Jeon, Tae Yong | - |
dc.contributor.author | Kim, Dae Hwan | - |
dc.contributor.author | Lee, Jae-Hyuck | - |
dc.contributor.author | Han, Sang-Uk | - |
dc.contributor.author | Song, Kyu Sang | - |
dc.contributor.author | Park, Dongmin | - |
dc.contributor.author | Park, Jun Won | - |
dc.contributor.author | Rodriguez, Henry | - |
dc.contributor.author | Kim, Jaesang | - |
dc.contributor.author | Lee, Hookeun | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Yang, Eun Gyeong | - |
dc.contributor.author | Kim, Hark Kyun | - |
dc.contributor.author | Paek, Eunok | - |
dc.contributor.author | Lee, Sanghyuk | - |
dc.contributor.author | Lee, Sang-Won | - |
dc.contributor.author | Hwang, Daehee | - |
dc.date.available | 2020-02-27T04:42:39Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-01-14 | - |
dc.identifier.issn | 1535-6108 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/1981 | - |
dc.description.abstract | We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune-and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.relation.isPartOf | CANCER CELL | - |
dc.subject | MICROSATELLITE INSTABILITY | - |
dc.subject | MOLECULAR SUBTYPES | - |
dc.subject | SIGNALING PATHWAY | - |
dc.subject | DATABASE SEARCH | - |
dc.subject | ACCURATE MASS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | MUTATIONS | - |
dc.subject | DISCOVERY | - |
dc.subject | GENE | - |
dc.subject | KINASE | - |
dc.title | Proteogenomic Characterization of Human Early-Onset Gastric Cancer | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000455719400012 | - |
dc.identifier.doi | 10.1016/j.ccell.2018.12.003 | - |
dc.identifier.bibliographicCitation | CANCER CELL, v.35, no.1, pp.111 - + | - |
dc.identifier.scopusid | 2-s2.0-85059409840 | - |
dc.citation.endPage | + | - |
dc.citation.startPage | 111 | - |
dc.citation.title | CANCER CELL | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Park, Jong Moon | - |
dc.contributor.affiliatedAuthor | Lee, Hookeun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | cancer subtypes | - |
dc.subject.keywordAuthor | correlation between mRNA and protein abundance changes | - |
dc.subject.keywordAuthor | correlation between mutation and phosphorylation | - |
dc.subject.keywordAuthor | diffuse gastric cancer | - |
dc.subject.keywordAuthor | proteogenomics | - |
dc.subject.keywordAuthor | somatic nonsynonymous mutations | - |
dc.subject.keywordPlus | MICROSATELLITE INSTABILITY | - |
dc.subject.keywordPlus | MOLECULAR SUBTYPES | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | DATABASE SEARCH | - |
dc.subject.keywordPlus | ACCURATE MASS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | DISCOVERY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | KINASE | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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