Colorectal Cancer Prognosis Is Not Associated with BRAF and KRAS Mutations-A STROBE Compliant Study
DC Field | Value | Language |
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dc.contributor.author | Lee, Joon-Hyop | - |
dc.contributor.author | Ahn, Jiyoung | - |
dc.contributor.author | Park, Won Seo | - |
dc.contributor.author | Choe, Eun Kyung | - |
dc.contributor.author | Kim, Eunyoung | - |
dc.contributor.author | Shin, Rumi | - |
dc.contributor.author | Heo, Seung Chul | - |
dc.contributor.author | Jung, Sohee | - |
dc.contributor.author | Kim, Kwangsoo | - |
dc.contributor.author | Chai, Young Jun | - |
dc.contributor.author | Chae, Heejoon | - |
dc.date.available | 2020-02-27T05:40:34Z | - |
dc.date.created | 2020-02-05 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2032 | - |
dc.description.abstract | Background: We investigated the associations between v-Raf murine sarcoma viral oncogene homolog B1 (BRAF(V600E), henceforth BRAF) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and colorectal cancer (CRC) prognosis, using The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GSE39582) datasets. Materials and Methods: The effects of BRAF and KRAS mutations on overall survival (OS) and disease-free survival (DFS) of CRC were evaluated. Results: The mutational status of BRAF and KRAS genes was not associated with overall survival (OS) or DFS of the CRC patients drawn from the TCGA database. The 3-year OS and DFS rates of the BRAF mutation (+) vs. mutation (-) groups were 92.6% vs. 90.4% and 79.7% vs. 68.4%, respectively. The 3-year OS and DFS rates of the KRAS mutation (+) vs. mutation (-) groups were 90.4% vs. 90.5% and 65.3% vs. 73.5%, respectively. In stage II patients, however, the 3-year OS rate was lower in the BRAF mutation (+) group than in the mutation (-) group (85.5% vs. 97.7%, p < 0.001). The mutational status of BRAF genes of 497 CRC patients drawn from the GSE39582 database was not associated with OS or DFS. The 3-year OS and DFS rates of BRAF mutation (+) vs. mutation (-) groups were 75.7% vs. 78.9% and 73.6% vs. 71.1%, respectively. However, KRAS mutational status had an effect on 3-year OS rate (71.9% mutation (+) vs. 83% mutation (-), p = 0.05) and DFS rate (66.3% mutation (+) vs. 74.6% mutation (-), p = 0.013). Conclusions: We found no consistent association between the mutational status of BRAF nor KRAS and the OS and DFS of CRC patients from the TCGA and GSE39582 databases. Studies with longer-term records and larger patient numbers may be necessary to expound the influence of BRAF and KRAS mutations on the outcomes of CRC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.title | Colorectal Cancer Prognosis Is Not Associated with BRAF and KRAS Mutations-A STROBE Compliant Study | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000457141100110 | - |
dc.identifier.doi | 10.3390/jcm8010111 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85064088761 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Joon-Hyop | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | BRAF | - |
dc.subject.keywordAuthor | KRAS | - |
dc.subject.keywordAuthor | overall survival | - |
dc.subject.keywordAuthor | disease-free survival | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | BENEFIT | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | ROLES | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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