Dual antiplatelet therapy beyond 12 months versus for 12 months after drug-eluting stents for acute myocardial infarction
DC Field | Value | Language |
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dc.contributor.author | Sim, D.S. | - |
dc.contributor.author | Jeong, M.H. | - |
dc.contributor.author | Kim, H.S. | - |
dc.contributor.author | Gwon, H.C. | - |
dc.contributor.author | Seung, K.B. | - |
dc.contributor.author | Rha, S.W. | - |
dc.contributor.author | Chae, S.C. | - |
dc.contributor.author | Kim, C.J. | - |
dc.contributor.author | Cha, K.S. | - |
dc.contributor.author | Park, J.S. | - |
dc.contributor.author | Yoon, J.H. | - |
dc.contributor.author | Chae, J.K. | - |
dc.contributor.author | Joo, S.J. | - |
dc.contributor.author | Choi, D.J. | - |
dc.contributor.author | Hur, S.H. | - |
dc.contributor.author | Seong, I.W. | - |
dc.contributor.author | Cho, M.C. | - |
dc.contributor.author | Kim, D.I. | - |
dc.contributor.author | Oh, S.K. | - |
dc.contributor.author | Ahn, T.H. | - |
dc.contributor.author | Hwang, J.Y. | - |
dc.date.available | 2020-02-27T05:40:49Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0914-5087 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2059 | - |
dc.description.abstract | Background: The optimal duration of dual antiplatelet therapy (DAPT) after acute coronary syndrome remains uncertain. This study investigated the benefit of DAPT beyond 12 months after drug-eluting stents (DES) for acute myocardial infarction (MI). Methods: From Korea Acute Myocardial Infarction Registry-National Institute of Health database, 6199 patients treated with DAPT for 12 months after DES (second-generation DES 98%) without ischemic or bleeding events were analyzed. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), a composite of death from any cause, MI, or ischemic stroke during the period from 12 to 24 months. Results: After adjustment using inverse probability of treatment weighting, patients who received DAPT beyond 12 months (n = 4795), compared to patients treated with 12-month DAPT (n = 1404), had a similar incidence of MACCE (1.3% vs. 1.0%, HR: 1.32, 95% CI: 0.71–2.45, p = 0.378). The 2 groups did not differ significantly in the rates of death (0.1% vs. 0.1%), MI (0.8% vs.0.6%), stent thrombosis (0.1% vs. 0.2%), ischemic stroke (0.4% vs. 0.2%), and major bleeding (0.1% vs. 0.1%). The rate of net adverse clinical events was 1.4% with DAPT beyond 12 months and 1.1% with 12-month DAPT (p = 0.466). Conclusions: DAPT beyond 12 months, as compared with 12-month DAPT, in real-world patients with acute MI treated predominantly with second-generation DES did not reduce the risk of MACCE. The rates of major bleeding and net adverse clinical events did not differ significantly between the 2 treatments. © 2019 Japanese College of Cardiology | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai) | - |
dc.relation.isPartOf | Journal of Cardiology | - |
dc.title | Dual antiplatelet therapy beyond 12 months versus for 12 months after drug-eluting stents for acute myocardial infarction | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000527373800011 | - |
dc.identifier.doi | 10.1016/j.jjcc.2019.06.006 | - |
dc.identifier.bibliographicCitation | Journal of Cardiology | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85072586455 | - |
dc.citation.title | Journal of Cardiology | - |
dc.contributor.affiliatedAuthor | Ahn, T.H. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antiplatelet agents | - |
dc.subject.keywordAuthor | Drug-eluting stents | - |
dc.subject.keywordAuthor | Myocardial infarction | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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