Expression of UTX Indicates Poor Prognosis in Patients with Luminal Breast Cancer and is Associated with MMP-11 Expression
DC Field | Value | Language |
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dc.contributor.author | Kim, G.J. | - |
dc.contributor.author | Kim, D.-H. | - |
dc.contributor.author | Min, K.-W. | - |
dc.contributor.author | Chae, S.W. | - |
dc.contributor.author | Kim, S.H. | - |
dc.contributor.author | Son, B.K. | - |
dc.contributor.author | Moon, K.M. | - |
dc.contributor.author | Kim, Y.H. | - |
dc.date.available | 2020-02-27T05:40:51Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1541-2016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2064 | - |
dc.description.abstract | Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) is involved in the epigenetic regulation. A previous mouse xenograft study revealed that UTX knockdown is associated with downregulated expression of matrix metalloproteinase-11 (MMP-11). The authors investigated 224 cases of breast cancer from Kangbuk Samsung Medical Center between 2000 and 2005. Nuclear UTX and cytoplasmic MMP-11 expressions were assessed using immunohistochemistry of tumor tissue microarray specimens. The relationships between the expression of UTX, MMP-11, and patients' outcomes were analyzed. UTX expression was significantly associated with high histologic grade, lymphatic invasion, vascular invasion, and tumoral expression of MMP-11. Survival analysis revealed that patients with UTX expression had a poorer overall survival rate (P= 0.010) as well as diminished disease-free survival rate (P= 0.001). The prognostic power of UTX expression was significant in patients with luminal-type breast cancer (P=0.027, overall survival; P=0.008, disease-free survival). Validation of UTX can provide further prognostic information beyond traditional indicators and represents a potential therapeutic target for breast cancer. © 2019 Wolters Kluwer Health, Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Lippincott Williams and Wilkins | - |
dc.relation.isPartOf | Applied Immunohistochemistry and Molecular Morphology | - |
dc.title | Expression of UTX Indicates Poor Prognosis in Patients with Luminal Breast Cancer and is Associated with MMP-11 Expression | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000570235200014 | - |
dc.identifier.doi | 10.1097/PAI.0000000000000795 | - |
dc.identifier.bibliographicCitation | Applied Immunohistochemistry and Molecular Morphology, v.28, no.7, pp.544 - 550 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85069692558 | - |
dc.citation.endPage | 550 | - |
dc.citation.startPage | 544 | - |
dc.citation.title | Applied Immunohistochemistry and Molecular Morphology | - |
dc.citation.volume | 28 | - |
dc.citation.number | 7 | - |
dc.contributor.affiliatedAuthor | Kim, G.J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | MMP-11 | - |
dc.subject.keywordAuthor | molecular classification | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | UTX | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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