In vivo screening of herbal extracts on high Glucose-induced changes in Hyaloid-retinal vessels of zebrafish
DC Field | Value | Language |
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dc.contributor.author | 이유리 | - |
dc.contributor.author | 정승현 | - |
dc.contributor.author | 이익수 | - |
dc.contributor.author | 김주환 | - |
dc.contributor.author | 김영숙 | - |
dc.contributor.author | 김진숙 | - |
dc.date.available | 2020-02-27T05:41:02Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.issn | 0253-3073 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2092 | - |
dc.description.abstract | The zebrafish (Danio rerio) is an established model organism for several pathophysiological conditions which are related to human diseases. In this study, we tested the preventive effect of eight herbal extracts, which show the inhibitory effect of advanced glycation end products (AGEs) or aldose reductase (AR) in our previous study, on high glucose (HG)-induced retinal vessel dilation in larval zebrafish and analyzed the change of hyaloid vasculature. HG-induced zebrafish hyaloid vasculatures were significantly increased in the thickness compared to untreated zebrafish (P<0.001, n=6~10). Eight herbal extracts were found to have significant retinal vessel dilation on the inhibitory activity. Particularly, Brandisia hancei (twigs and fruits), Castanopsis orthacantha (leaves and twigs), Litsea japonica (leaves and twigs), Spenceria ramalana (whole plant), and Synedrella nodiflora (leaves and stems) showed potent inhibitory activity against retinal vessel dilation in HG-induced larval zebrafish. © 2019 Korean Journal of Pharmacognosy. All rights reserved. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | Korean Society of Pharmacognosy | - |
dc.relation.isPartOf | Korean Journal of Pharmacognosy | - |
dc.title | In vivo screening of herbal extracts on high Glucose-induced changes in Hyaloid-retinal vessels of zebrafish | - |
dc.title.alternative | 고혈당으로 유도된 제브라피쉬 당뇨망막병증 모델에서 약용식물의 효능 평가 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pharmacognosy, v.50, no.1, pp.25 - 31 | - |
dc.identifier.kciid | ART002451877 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85069429435 | - |
dc.citation.endPage | 31 | - |
dc.citation.startPage | 25 | - |
dc.citation.title | Korean Journal of Pharmacognosy | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 김주환 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Diabetic complications | - |
dc.subject.keywordAuthor | Diabetic retinopathy | - |
dc.subject.keywordAuthor | Herbal medicines | - |
dc.subject.keywordAuthor | Zebrafish | - |
dc.subject.keywordPlus | advanced glycation end product | - |
dc.subject.keywordPlus | aldehyde reductase | - |
dc.subject.keywordPlus | Brandisia hancei extract | - |
dc.subject.keywordPlus | Castanopsis orthacantha extract | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | Litsea japonica extract | - |
dc.subject.keywordPlus | plant extract | - |
dc.subject.keywordPlus | Spenceria ramalana extract | - |
dc.subject.keywordPlus | Synedrella nodiflora extract | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | vasodilator agent | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | blood vessel wall | - |
dc.subject.keywordPlus | Brandisia hancei | - |
dc.subject.keywordPlus | Castanopsis orthacantha | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | Litsea japonica | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | plant | - |
dc.subject.keywordPlus | retinal vascular disease | - |
dc.subject.keywordPlus | Spenceria ramalana | - |
dc.subject.keywordPlus | Synedrella nodiflora | - |
dc.subject.keywordPlus | vasodilatation | - |
dc.subject.keywordPlus | zebra fish | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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