Diol-ginsenosides from Korean Red Ginseng delay the development of type 1 diabetes in diabetes-prone biobreeding rats
DC Field | Value | Language |
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dc.contributor.author | Ju, C. | - |
dc.contributor.author | Jeon, S.-M. | - |
dc.contributor.author | Jun, H.-S. | - |
dc.contributor.author | Moon, C.-K. | - |
dc.date.available | 2020-02-27T05:41:08Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2107 | - |
dc.description.abstract | Background: The effects of diol-ginsenoside fraction (Diol-GF) and triol-ginsenoside fraction (Triol-GF) from Korean Red Ginseng on the development of type 1 diabetes (T1D) were examined in diabetes-prone biobreeding (DP-BB) rats that spontaneously develop T1D through an autoimmune process. Methods: DP-BB female rats were treated with Diol-GF or Triol-GF daily from the age of 3–4 weeks up to 11–12 weeks (1 mg/g body weight). Results: Diol-GF delayed the onset, and reduced the incidence, of T1D. Islets of Diol-GF–treated DP-BB rats showed significantly lower insulitis and preserved higher plasma and pancreatic insulin levels. Diol-GF failed to change the proportion of lymphocyte subsets such as T cells, natural killer cells, and macrophages in the spleen and blood. Diol-GF had no effect on the ability of DP-BB rat splenocytes to induce diabetes in recipients. Diol-GF and diol-ginsenoside Rb1 significantly decreased tumor necrosis factor α production, whereas diol-ginsenosides Rb1 and Rd decreased interleukin 1β production in RAW264.7 cells. Furthermore, mixed cytokine- and chemical-induced β-cell cytotoxicity was greatly inhibited by Diol-GF and diol-ginsenosides Rc and Rd in RIN5mF cells. However, nitric oxide production in RAW264.7 cells was unaffected by diol-ginsenosides. Conclusion: Diol-GF, but not Triol-GF, significantly delayed the development of insulitis and T1D in DP-BB rats. The antidiabetogenic action of Diol-GF may result from the decrease in cytokine production and increase in β-cell resistance to cytokine/free radical–induced cytotoxicity. © 2019 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC GINSENG | - |
dc.relation.isPartOf | Journal of Ginseng Research | - |
dc.title | Diol-ginsenosides from Korean Red Ginseng delay the development of type 1 diabetes in diabetes-prone biobreeding rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000543466000011 | - |
dc.identifier.doi | 10.1016/j.jgr.2019.06.001 | - |
dc.identifier.bibliographicCitation | Journal of Ginseng Research, v.44, no.4, pp.619 - 626 | - |
dc.identifier.kciid | ART002605829 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85068222549 | - |
dc.citation.endPage | 626 | - |
dc.citation.startPage | 619 | - |
dc.citation.title | Journal of Ginseng Research | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Jun, H.-S. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Diol-ginsenosides | - |
dc.subject.keywordAuthor | Type 1 diabetes | - |
dc.subject.keywordAuthor | β-cell cytotoxicity | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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