Mitigation effects of red Platycodon grandiflorum extract on lipopolysaccharide-induced inflammation in splenocytes isolated from mice*
DC Field | Value | Language |
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dc.contributor.author | Park, E.-J. | - |
dc.contributor.author | Lee, Y.-S. | - |
dc.contributor.author | Jeong, H.C. | - |
dc.contributor.author | Lee, S.-H. | - |
dc.contributor.author | Lee, H.-J. | - |
dc.date.available | 2020-02-27T05:41:09Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 2288-3886 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2109 | - |
dc.description.abstract | Purpose: Platycodon grandiflorum (PG) is known to have effective antimicrobial and anticancer activity. The main bioactive components of PG are saponins, and these could contribute to anti-inflammatory activity. However, little is known about the anti-inflammatory effect of PG. In this study, we aim to assess the anti-inflammatory response to Red PG Extract (RPGE) in splenocytes under ex vivo conditions. Methods: The cell viability of isolated splenocytes taken from mice was analyzed by performing a Cell Counting Kit-8 assay. The productions of nitric oxide (NO) and cytokines (specifically interleukin-6 (IL-6) and interleukin-10 (IL-10)) were measured utilizing Griess reagent and ELISA, respectively. Results: We found that co-treatment with RPGE and Lipopolysaccharide (LPS) decreased isolated splenocyte proliferation as compared with that of the LPS-stimulated control. We also observed that RPGE markedly suppressed NO synthesis and IL-6 production that was induced by LPS. There were no significant differences of IL-10 production between co-treatment with RPGE plus LPS and treatment with LPS alone. Conclusion: When taken together, our data has shown that RPGE mitigates LPS-induced inflammation in splenocytes isolated from mice. Further research is surely needed to confirm the anti-inflammation effects of RPGE in an in vivo model. © 2019 The Korean Nutrition Society | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | Korean Nutrition Society | - |
dc.relation.isPartOf | Journal of Nutrition and Health | - |
dc.title | Mitigation effects of red Platycodon grandiflorum extract on lipopolysaccharide-induced inflammation in splenocytes isolated from mice* | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.doi | 10.4163/jnh.2019.52.3.243 | - |
dc.identifier.bibliographicCitation | Journal of Nutrition and Health, v.52, no.3, pp.243 - 249 | - |
dc.identifier.kciid | ART002479099 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85071695312 | - |
dc.citation.endPage | 249 | - |
dc.citation.startPage | 243 | - |
dc.citation.title | Journal of Nutrition and Health | - |
dc.citation.volume | 52 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Park, E.-J. | - |
dc.contributor.affiliatedAuthor | Lee, Y.-S. | - |
dc.contributor.affiliatedAuthor | Lee, H.-J. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Platycodon grandiflorum | - |
dc.subject.keywordAuthor | Splenocytes | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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