Anti-inflammatory Effect of Eucommia Ulmoides Oliver Bark Extract on P.gingivalis LPS-induced YD-38 Cells두충 추출물의 잇몸상피세포 염증에 대한 항염증 효과
- Other Titles
- 두충 추출물의 잇몸상피세포 염증에 대한 항염증 효과
- Authors
- 김현영; 김예진; 허웅; 최한석; 강기성; 황귀서; 백지윤; 구본암
- Issue Date
- Sep-2019
- Publisher
- 한국생약학회
- Keywords
- Periodontitis; Eucommia ulmoides oliv. bark (EU); Anti-inflammation; Porphyromonas gingivalis-lps (LPS-PG); YD-38 cells
- Citation
- 생약학회지, v.50, no.3, pp.185 - 190
- Journal Title
- 생약학회지
- Volume
- 50
- Number
- 3
- Start Page
- 185
- End Page
- 190
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2234
- ISSN
- 0253-3073
- Abstract
- Periodontitis is a chronic inflammatory disease and gums pull away from the teeth and form spaces. The main goal of treatment is to control the infection and anti-inflammation. Eucommia ulmoides Oliv. Bark (EU) is a traditional Korean herbal used for the treatment of arthritis and hypertension. In the present study, we investigated the anti-inflammatory properties of EU in Porphyromonas gingivalis-LPS (LPS-PG) induced YD-38 epithelial cells. We observed significant inhibition of nitric oxide (NO) production and the expression of interleukin-8 (IL-8), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-a), cyclooxygenase-2 (COX-2) in LPS-PG-induced YD-38 cells. These results support that EU has an anti-inflammatory effects for the treatment of periodontitis.
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