Aged Doraji (Platycodon grandiflorum) Ameliorates Cyclophosphamide-Induced Immunosuppression in Mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이성현 | - |
dc.contributor.author | 최지혜 | - |
dc.contributor.author | 이은별 | - |
dc.contributor.author | 박양규 | - |
dc.contributor.author | 이혜경 | - |
dc.contributor.author | 장환희 | - |
dc.contributor.author | 최정숙 | - |
dc.contributor.author | 황경아 | - |
dc.contributor.author | 박신영 | - |
dc.contributor.author | 황인국 | - |
dc.contributor.author | 홍하철 | - |
dc.contributor.author | 이해정 | - |
dc.contributor.author | 정현철 | - |
dc.contributor.author | 김현주 | - |
dc.date.available | 2020-02-27T05:42:09Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 0253-3073 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2254 | - |
dc.description.abstract | This study was done to examine immunomodulative effects of aged doraji (AD) in the immune-suppressed mice induced by cyclophosphamide. The immune-stimulating effects of ethanol AD extract in in vivo at 75 and 150 mg/kg body weight (BW) for AD and 2AD groups were evaluated and compared to the normal doraji group (2ND, 150 mg/kg BW) treated with a doraji without aging process. After the 10 days of oral supplement, body and immune related organ weights, serum immunoglobulin G (IgG) and cytokines levels, splenocytes proliferation rate, and splenic NK cell activity were measured as immune-related biomarkers. Body weight and serum IgG level increased in the 2AD group. But, the serum Th2 cytokine (IL-6, TNF-a) levels were lower in the AD and 2AD groups, respectively. Splenic T cell and B cell proliferation and NK cell activity increased in the doraji groups and the significant increases were found only in the 2AD group. Thus, the aged doraji extract may affect body weight, serum IgG level, splenocytes proliferation, and splenic NK cell activity, and normalize the Th2 cytokine levels in the immune-suppressed mice. The results suggest that the aged doraji improves effectively immune system rather than the normal one. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국생약학회 | - |
dc.relation.isPartOf | 생약학회지 | - |
dc.title | Aged Doraji (Platycodon grandiflorum) Ameliorates Cyclophosphamide-Induced Immunosuppression in Mice | - |
dc.title.alternative | Cyclophosphamide에 의해 유도된 면역저하 마우스 모델에서 홍도라지 추출물의 면역 기능 조절 효과 | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.bibliographicCitation | 생약학회지, v.50, no.3, pp.219 - 225 | - |
dc.identifier.kciid | ART002509532 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85076316403 | - |
dc.citation.endPage | 225 | - |
dc.citation.startPage | 219 | - |
dc.citation.title | 생약학회지 | - |
dc.citation.volume | 50 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | 이해정 | - |
dc.subject.keywordAuthor | Platycodon grandiflorum | - |
dc.subject.keywordAuthor | Immune | - |
dc.subject.keywordAuthor | Splenocyte proliferation | - |
dc.subject.keywordAuthor | Serum cytokine | - |
dc.subject.keywordAuthor | NK cell activity | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.