Parathyroid Cancer: Comparison with Benign Hyperparathyroidism
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 석재연 | - |
dc.contributor.author | 이준협 | - |
dc.contributor.author | 이시훈 | - |
dc.contributor.author | 강석하 | - |
dc.contributor.author | 정유승 | - |
dc.date.available | 2020-02-27T06:41:18Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2019-06 | - |
dc.identifier.issn | 2508-8149 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2449 | - |
dc.description.abstract | Purpose: The preoperative diagnosis of parathyroid cancer (PC) is challenging. The purpose of this study was to identify the differences between PC and benign primary hyperparathyroidism. Methods: The medical records of 85 hyperparathyroidism patients that underwent surgery between 2001 and 2017 were retrospectively reviewed. Results: Seven of the 85 were diagnosed with PC. Mean age was 53.0±13.0 years and 66 (77.6%) were women. Follow-up duration was 52.9±44.4 months. Tumors were larger (3.50±1.26 cm vs. 2.10±0.84 cm, P=0.002), and intact parathyroid hormone (iPTH) (1,142.8±524.5 pg/mL vs. 461.2±513.5 pg/mL, P=0.002) and alkaline phosphatase (ALP) (398.6±493.6 U/L vs. 166.7±181.1 U/L, P=0.01) levels were higher in cancer patients than in benign primary hyperparathyroidism. Intraoperatively, adhesion to surrounding soft tissue or the thyroid gland was detected more frequently in cancer (85.7% vs. 12.8%, P<0.001). Two patients experienced recurrences and one of them died from PC. Conclusion: PC patients had larger tumors size, and higher serum iPTH and ALP levels. Intraoperative detection of adhesion to surrounding soft tissue/thyroid importantly raised suspicion of PC. Surgeons operating for hyperparathyroidism should be prepared to perform an appropriate en bloc resection initially upon suspicion of PC. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한갑상선-내분비외과학회 | - |
dc.relation.isPartOf | The Journal of Endocrine Surgery | - |
dc.title | Parathyroid Cancer: Comparison with Benign Hyperparathyroidism | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | The Journal of Endocrine Surgery, v.19, no.2, pp.35 - 44 | - |
dc.identifier.kciid | ART002476040 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 44 | - |
dc.citation.startPage | 35 | - |
dc.citation.title | The Journal of Endocrine Surgery | - |
dc.citation.volume | 19 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 석재연 | - |
dc.contributor.affiliatedAuthor | 이준협 | - |
dc.contributor.affiliatedAuthor | 이시훈 | - |
dc.contributor.affiliatedAuthor | 강석하 | - |
dc.contributor.affiliatedAuthor | 정유승 | - |
dc.subject.keywordAuthor | Keywords: Parathyroid neoplasms | - |
dc.subject.keywordAuthor | Hyperparathyroidism | - |
dc.subject.keywordAuthor | Parathyroid cancer | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
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