한수대보원이 포유동물인 생쥐 모델에서 골 손실 및 RANKL 유도 파골세포 분화에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 장시성 | - |
dc.contributor.author | 류홍선 | - |
dc.contributor.author | 전찬용 | - |
dc.contributor.author | 황귀서 | - |
dc.date.available | 2020-02-27T06:42:03Z | - |
dc.date.created | 2020-02-12 | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1226-9174 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2557 | - |
dc.description.abstract | Objective: This study investigated the effects of Hansu-Daebowon (HDW) on bone resorption in vitro and bone loss in vivo. Methods: Osteoclast differentiation was measured by counting TRAP (+) MNC formed from RAW 264.7 in the presence of RANKL. Bone pit formation was determined in an artificial bone slice loaded with RANKL-stimulated osteoclasts. To elucidate the mechanisms of the inhibitory effects of HDW on bone resorption and osteoclast differentiation, osteoclastogenic genes (i.e. TRAP, MMP-9, NFATc1, c-Fos, and Cathepsin K) were measured using real time PCR. Furthermore, bone loss was observed using micro-CT in an LPS-treated mammal model. Results: HDW inhibited the bone pit formation in vitro and inhibited bone loss in vivo. Moreover, HDW decreased the number of TRAP (+) MNCs in the presence of RANKL, and HDW inhibited the expressions of cathepsin K, MMP-9, TRAP, NFATc1, and c-Fos in the osteoclasts. Conclusion: HDW exerts inhibitory effects on bone loss and bone resorption resulting from the inhibitions of osteoclast differentiation and osteoclastogenic gene expression. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한방내과학회 | - |
dc.relation.isPartOf | 대한한방내과학회지 | - |
dc.title | 한수대보원이 포유동물인 생쥐 모델에서 골 손실 및 RANKL 유도 파골세포 분화에 미치는 영향 | - |
dc.title.alternative | Effects of Hansu-Daebowon (HDW) on RANKL-induced Osteoclast Differentiation and Bone Loss in Mammal Model | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한한방내과학회지, v.40, no.1, pp.58 - 69 | - |
dc.identifier.kciid | ART002456693 | - |
dc.citation.endPage | 69 | - |
dc.citation.startPage | 58 | - |
dc.citation.title | 대한한방내과학회지 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 장시성 | - |
dc.contributor.affiliatedAuthor | 전찬용 | - |
dc.contributor.affiliatedAuthor | 황귀서 | - |
dc.subject.keywordAuthor | Hansu-Daebowon (HDW) | - |
dc.subject.keywordAuthor | osteoclast differentiation | - |
dc.subject.keywordAuthor | TRAP | - |
dc.subject.keywordAuthor | cathepsin K | - |
dc.subject.keywordAuthor | NFATc1 | - |
dc.subject.keywordAuthor | bone loss | - |
dc.subject.keywordAuthor | bone resorption | - |
dc.description.journalRegisteredClass | kci | - |
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