Oseltamivir 복용 이후 소아에서 발생한 이상행동 및 그 인과성 평가Psychiatric Symptoms after Taking Oseltamivir in a Child and Its Causality Assessment
- Other Titles
- Psychiatric Symptoms after Taking Oseltamivir in a Child and Its Causality Assessment
- Authors
- 손병우; 최중혁; 이승민; 박선순; 최은경; 유봉규; 지은희
- Issue Date
- Mar-2019
- Publisher
- 한국임상약학회
- Keywords
- Oseltamivir; adverse event; psychiatric symptom; causality assessment; community pharmacy
- Citation
- 한국임상약학회지, v.29, no.1, pp.56 - 60
- Journal Title
- 한국임상약학회지
- Volume
- 29
- Number
- 1
- Start Page
- 56
- End Page
- 60
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/2599
- ISSN
- 1226-6051
- Abstract
- Oseltamivir is an antiviral medication prescribed to prevent and treat influenza A and B. A case from a community pharmacy in Korea was reported for an adverse event associated with oseltamivir administration. A 20-month-old boy had psychiatric symptoms after receiving 2 doses of oseltamivir. Therefore, an evaluation of whether the psychiatric symptoms were caused by oseltamivir was required. To determine whether the adverse event resulted from the administrated medication or other factors, three tools were used: the Naranjo scale, the Korean causality assessment algorithm (Ver.2), and the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria. The psychiatric symptoms occurred after oseltamivir administration, and were attenuated after oseltamivir termination. A possible cause of the psychiatric symptoms is high fever, but information on the body temperature of the patient was not sufficient. Therefore, it was unclear whether there were other nonpharmacological causes of adverse drug reaction.
For these reasons, in terms of causality, the results evaluated by the three tools represented, "possible", "probable", and "probable/ likely", respectively.
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