Microneedle Array Patch (MAP) Consisting of Crosslinked Hyaluronic Acid Nanoparticles for Processability and Sustained Release
DC Field | Value | Language |
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dc.contributor.author | Kim, Dae-Sung | - |
dc.contributor.author | Choi, Jun-Tae | - |
dc.contributor.author | Kim, Cheong Bi | - |
dc.contributor.author | Shin, Yu-Ra | - |
dc.contributor.author | Park, Pil-Gu | - |
dc.contributor.author | Kim, Hyemi | - |
dc.contributor.author | Lee, Jae Myun | - |
dc.contributor.author | Park, Jung-Hwan | - |
dc.date.available | 2020-04-06T06:37:49Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-02-07 | - |
dc.identifier.issn | 0724-8741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26099 | - |
dc.description.abstract | Aims Crosslinked hyaluronic acid (X-linked HA) is not suitable for making microneedles because of the low fluidity of X-linked HA hydrogel. Microneedles were fabricated using X-linked HA nanoparticles (X-linked HA-NPs) to utilize the sustained drug delivery capability of X-linked HA-NPs and to obtain the processability advantages of X-linked HA. Method The puncture performance of a microneedle array patch (MAP) made of crosslinked hyaluronic acid nanoparticles (X-linked HA-NP-MAP) was evaluated by insertion in vitro into porcine skin. After a predetermined attachment time, the remaining height of the X-linked HA-NP-MAP was measured to determine the dissolution rate. X-linked HA-NP-MAP and free HA-MAP containing Rhodamine B isothiocyanate-dextran were administered into the back skin of mice, and the relative fluorescent intensity in the back skin was measured over time. Results The puncture performance of the X-linked HA-NP-MAP was over 90%. The diameter of redispersed X-linked HA-NPs was same as that of the premolded X-linked HA-NPs. The dissolution rate was not different from that of free HA-MAP. In an in vivo experiment, X-linked HA-NP-MAP was administered into the mouse's back skin successfully and the relative fluorescent intensity of X-linked HA-NP-MAP lasted longer than that of HA-MAP. Conclusion X-linked HA-NPs provide the biocompatibility, the processability of micromolding, sustained drug release, successful penetration into the skin, and relatively short insertion time for full disintegration of NPs in the skin. X-linked HA-NP-MAP can be used for various applications that require several days of sustained drug release. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER/PLENUM PUBLISHERS | - |
dc.relation.isPartOf | PHARMACEUTICAL RESEARCH | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | TUMOR | - |
dc.title | Microneedle Array Patch (MAP) Consisting of Crosslinked Hyaluronic Acid Nanoparticles for Processability and Sustained Release | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000513265600001 | - |
dc.identifier.doi | 10.1007/s11095-020-2768-3 | - |
dc.identifier.bibliographicCitation | PHARMACEUTICAL RESEARCH, v.37, no.3 | - |
dc.identifier.scopusid | 2-s2.0-85079073290 | - |
dc.citation.title | PHARMACEUTICAL RESEARCH | - |
dc.citation.volume | 37 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Sung | - |
dc.contributor.affiliatedAuthor | Choi, Jun-Tae | - |
dc.contributor.affiliatedAuthor | Shin, Yu-Ra | - |
dc.contributor.affiliatedAuthor | Park, Jung-Hwan | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | crosslinked hyaluronic acid | - |
dc.subject.keywordAuthor | microneedles | - |
dc.subject.keywordAuthor | nanoparticles | - |
dc.subject.keywordAuthor | processability | - |
dc.subject.keywordAuthor | puncture performance | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | TUMOR | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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