Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions
DC Field | Value | Language |
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dc.contributor.author | Jung, Hyun Jin | - |
dc.contributor.author | Kang, Ju-Hee | - |
dc.contributor.author | Pak, Seongwon | - |
dc.contributor.author | Lee, Keunwook | - |
dc.contributor.author | Seong, Je Kyung | - |
dc.contributor.author | Oh, Seung Hyun | - |
dc.date.available | 2020-04-06T06:39:29Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-01-02 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26155 | - |
dc.description.abstract | Nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a cell-surface adhesion molecule that regulates cell migration and attachment. This study demonstrates the increase in Ninj1 protein expression during development of intestinal inflammation. Ninj1-deficient mice exhibited significantly attenuated bodyweight loss, shortening of colon length, intestinal inflammation, and lesser pathological lesions than wild-type mice. Although more severe inflammation and serious lesions are observed in wild-type mice than Ninj1-deficient mice, there were no changes in the numbers of infiltrating macrophages in the inflamed tissues obtained from WT and Ninj1-deficient mice. Ninj1 expression results in activation of macrophages, and these activated macrophages secrete more cytokines and chemokines than Ninj1-deficient macrophages. Moreover, mice with conditional deletion of Ninj1 in myeloid cells (Ninj1(fl/fl); Lyz-Cre+) alleviated experimental colitis compared with wild-type mice. In summary, we propose that the Ninj1 in myeloid cells play a pivotal function in intestinal inflammatory conditions. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | LUNG-CANCER CELLS | - |
dc.subject | ULCERATIVE-COLITIS | - |
dc.subject | CROHNS-DISEASE | - |
dc.subject | CYTOKINE PRODUCTION | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | NINJURIN1 | - |
dc.subject | MACROPHAGES | - |
dc.subject | INHIBITION | - |
dc.subject | MIGRATION | - |
dc.subject | ACTIVATION | - |
dc.title | Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000515380000244 | - |
dc.identifier.doi | 10.3390/ijms21020614 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.2 | - |
dc.identifier.scopusid | 2-s2.0-85078210828 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kang, Ju-Hee | - |
dc.contributor.affiliatedAuthor | Oh, Seung Hyun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Ninjurin1 | - |
dc.subject.keywordAuthor | myeloid cells | - |
dc.subject.keywordAuthor | IL1 beta | - |
dc.subject.keywordAuthor | IBD | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordPlus | LUNG-CANCER CELLS | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | NINJURIN1 | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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