The Fundamental Role of Bicarbonate Transporters and Associated Carbonic Anhydrase Enzymes in Maintaining Ion and pH Homeostasis in Non-Secretory Organs
DC Field | Value | Language |
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dc.contributor.author | Lee, Dongun | - |
dc.contributor.author | Hong, Jeong Hee | - |
dc.date.available | 2020-04-06T06:39:38Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26161 | - |
dc.description.abstract | The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport leads to various diseases, including immune disorders, cystic fibrosis, tumorigenesis, kidney diseases, brain dysfunction, tooth fracture, ischemic reperfusion injury, hypertension, impaired reproductive system, and systemic acidosis. Carbonic anhydrases are involved in the mechanism of bicarbonate movement and consist of complex of bicarbonate transport systems including bicarbonate transporters. This review focused on the convergent regulation of ion homeostasis through various ion transporters including bicarbonate transporters, their regulatory enzymes, such as carbonic anhydrases, pH regulatory role, and the expression pattern of ion transporters in non-secretory systems throughout the body. Understanding the correlation between these systems will be helpful in order to obtain new insights and design potential therapeutic strategies for the treatment of pH-related disorders. In this review, we have discussed the broad prospects and challenges that remain in elucidation of bicarbonate-transport-related biological and developmental systems. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.subject | NA+HCO3-COTRANSPORTER NBCN1 | - |
dc.subject | EPITHELIAL SODIUM-CHANNEL | - |
dc.subject | MALE REPRODUCTIVE-TRACT | - |
dc.subject | NA+/H+ EXCHANGER NHE1 | - |
dc.subject | INTRACELLULAR PH | - |
dc.subject | CL-/HCO3-EXCHANGER | - |
dc.subject | BREAST-CANCER | - |
dc.subject | ANION TRANSPORTER | - |
dc.subject | CHLORIDE CHANNEL | - |
dc.subject | BINDING PROTEIN | - |
dc.title | The Fundamental Role of Bicarbonate Transporters and Associated Carbonic Anhydrase Enzymes in Maintaining Ion and pH Homeostasis in Non-Secretory Organs | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000515378000339 | - |
dc.identifier.doi | 10.3390/ijms21010339 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.1 | - |
dc.identifier.scopusid | 2-s2.0-85078065400 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Dongun | - |
dc.contributor.affiliatedAuthor | Hong, Jeong Hee | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | bicarbonate | - |
dc.subject.keywordAuthor | ion transporters | - |
dc.subject.keywordAuthor | carbonic anhydrase | - |
dc.subject.keywordAuthor | intracellular pH | - |
dc.subject.keywordAuthor | maturation | - |
dc.subject.keywordPlus | NA+HCO3-COTRANSPORTER NBCN1 | - |
dc.subject.keywordPlus | EPITHELIAL SODIUM-CHANNEL | - |
dc.subject.keywordPlus | MALE REPRODUCTIVE-TRACT | - |
dc.subject.keywordPlus | NA+/H+ EXCHANGER NHE1 | - |
dc.subject.keywordPlus | INTRACELLULAR PH | - |
dc.subject.keywordPlus | CL-/HCO3-EXCHANGER | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | ANION TRANSPORTER | - |
dc.subject.keywordPlus | CHLORIDE CHANNEL | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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