Altered T cell and monocyte subsets in prolonged immune reconstitution inflammatory syndrome related with DRESS (drug reaction with eosinophilia and systemic symptoms)
DC Field | Value | Language |
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dc.contributor.author | Kang, Sung-Yoon | - |
dc.contributor.author | Kim, Jihyun | - |
dc.contributor.author | Ham, Jongho | - |
dc.contributor.author | Cho, Sang-Heon | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.contributor.author | Kim, Hye Young | - |
dc.date.available | 2020-04-06T06:40:07Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2233-8276 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26175 | - |
dc.description.abstract | Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous adverse reaction involving various internal organs. Flare-ups after recovery from the initial presentation of DRESS are caused by relapse of drug-induced T-cell-mediated reactions. However, the specific underlying mechanism is unclear. Here, we report a case of a 60-year-old man with allopurinol-induced DRESS who suffered recurrent episodes of generalized rash with eosinophilia, which mimicked immune reconstitution inflammatory syndrome. Analysis of immunological profiles revealed that the percentages of T lymphocytes and regulatory T cells in the patient with DRESS were higher than those in healthy controls. In addition, there was a notable change in the subtype of monocytes in the patient with DRESS; the percentage of nonclassical monocytes increased, whereas that of classical monocytes decreased. Upon viral infection, nonclassical monocytes exhibited strong proinflammatory properties that skewed the immune response toward a Th2 profile, which was associated with persistent flare-ups of DRESS. Taken together, the results increase our understanding of the pathogenesis of DRESS as they suggest that expansion of nonclassical monocytes and Th2 cells drives disease pathogenesis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ASIA PACIFIC ASSOC ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY | - |
dc.relation.isPartOf | ASIA PACIFIC ALLERGY | - |
dc.title | Altered T cell and monocyte subsets in prolonged immune reconstitution inflammatory syndrome related with DRESS (drug reaction with eosinophilia and systemic symptoms) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000514547700002 | - |
dc.identifier.doi | 10.5415/apallergy.2020.10.e2 | - |
dc.identifier.bibliographicCitation | ASIA PACIFIC ALLERGY, v.10, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.citation.title | ASIA PACIFIC ALLERGY | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kang, Sung-Yoon | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | DRESS syndrome | - |
dc.subject.keywordAuthor | Allopurinol | - |
dc.subject.keywordAuthor | Herpesviruses | - |
dc.subject.keywordAuthor | Immune reconstitution | - |
dc.subject.keywordPlus | HYPERSENSITIVITY-SYNDROME | - |
dc.subject.keywordPlus | REACTIVATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | RASH | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
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