Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | Jin, Wook | - |
dc.date.available | 2020-04-06T06:40:10Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26177 | - |
dc.description.abstract | Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic neurons of the substantia nigra and plays a critical role in neurophysiological processes, including neuro-protection and maturation and maintenance of neurons. The activation as well as dysfunction of the BDNF-TrkB pathway are associated with neurodegenerative diseases. The expression of BDNF/TrkB in the substantia nigra is significantly reduced in Parkinson's Disease (PD) patients. This review summarizes recent progress in the understanding of the cellular and molecular roles of BNDF/TrkB signaling and its isoform, TrkB.T1, in Parkinson's disease. We have also discussed the effects of current therapies on BDNF/TrkB signaling in Parkinson's disease patients and the mechanisms underlying the mutation-mediated acquisition of resistance to therapies for Parkinson's disease. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.title | Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000515388400257 | - |
dc.identifier.doi | 10.3390/jcm9010257 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.9, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85087877428 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Jin, Wook | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | TrkB | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | BDNF | - |
dc.subject.keywordAuthor | TrkB isoform | - |
dc.subject.keywordAuthor | neuronal degeneration | - |
dc.subject.keywordPlus | SPINAL-CORD-INJURY | - |
dc.subject.keywordPlus | NEUROTROPHIC FACTOR | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | SUBSTANTIA-NIGRA | - |
dc.subject.keywordPlus | DOPAMINERGIC-NEURONS | - |
dc.subject.keywordPlus | TRUNCATED TRKB | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | RECEPTOR EXPRESSION | - |
dc.subject.keywordPlus | INDUCED DYSKINESIA | - |
dc.subject.keywordPlus | NEUROPATHIC PAIN | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
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