Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals
DC Field | Value | Language |
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dc.contributor.author | Lee, Sullim | - |
dc.contributor.author | Jegal, Hyun | - |
dc.contributor.author | Bong, Sim-Kyu | - |
dc.contributor.author | Yoon, Kyeong-No | - |
dc.contributor.author | Park, No-June | - |
dc.contributor.author | Shin, Myoung-Sook | - |
dc.contributor.author | Yang, Min Hye | - |
dc.contributor.author | Kim, Yong Kee | - |
dc.contributor.author | Kim, Su-Nam | - |
dc.date.available | 2020-04-06T06:40:15Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2218-273X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26180 | - |
dc.description.abstract | To investigate the potential effects of acorn shells on atopic dermatitis (AD), we utilized oxazolone (OX)- or 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesion mouse models. Our research demonstrates that Acorn shell extract (ASE) improved the progression of AD-like lesions, including swelling, which were induced by oxazolone on Balb/c mouse ears. Additionally, ASE significantly decreased the ear thickness (OX: 0.42 +/- 0.01 mm, OX-ASE: 0.32 +/- 0.02 mm) and epidermal thickness (OX: 75.3 +/- 32.6 mu m, OX-ASE: 46.1 +/- 13.4 mu m). The continuous DNCB-induced AD mouse model in SKH-1 hairless mice demonstrated that ASE improved AD-like symptoms, including the recovery of skin barrier dysfunction, Immunoglobulin E hyperproduction (DNCB: 340.1 +/- 66.8 ng/mL, DNCB-ASE: 234.8 +/- 32.9 ng/mL) and an increase in epidermal thickness (DNCB: 96.4 +/- 21.9 mu m, DNCB-ASE: 52.4 +/- 16.3 mu m). In addition, we found that ASE suppressed the levels of AD-involved cytokines, such as Tumor Necrosis Factor alpha, IL-1 beta, IL-25 and IL-33 in both animal models. Furthermore, gallic acid and ellagic acid isolated from ASE suppressed beta-hexosaminidase release and IL-4 expression in RBL-2H3 cells. The acorn shell and its active phytochemicals have potential as a new remedy for the improvement of atopic dermatitis and other inflammatory diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | BIOMOLECULES | - |
dc.subject | T-CELL CLONES | - |
dc.subject | SKIN BARRIER | - |
dc.subject | ELLAGIC ACID | - |
dc.subject | MURINE MODEL | - |
dc.subject | MAST-CELLS | - |
dc.subject | IGE | - |
dc.subject | INHIBITION | - |
dc.subject | IL-4 | - |
dc.subject | PIMECROLIMUS | - |
dc.subject | OXAZOLONE | - |
dc.title | Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000514863200124 | - |
dc.identifier.doi | 10.3390/biom10010057 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES, v.10, no.1 | - |
dc.identifier.scopusid | 2-s2.0-85077603770 | - |
dc.citation.title | BIOMOLECULES | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Lee, Sullim | - |
dc.contributor.affiliatedAuthor | Shin, Myoung-Sook | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | acorn shell | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | IL-4 | - |
dc.subject.keywordAuthor | gallic acid | - |
dc.subject.keywordAuthor | ellagic acid | - |
dc.subject.keywordPlus | T-CELL CLONES | - |
dc.subject.keywordPlus | SKIN BARRIER | - |
dc.subject.keywordPlus | ELLAGIC ACID | - |
dc.subject.keywordPlus | MURINE MODEL | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | IGE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | IL-4 | - |
dc.subject.keywordPlus | PIMECROLIMUS | - |
dc.subject.keywordPlus | OXAZOLONE | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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