The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation
DC Field | Value | Language |
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dc.contributor.author | Kyung-Ok Kim | - |
dc.contributor.author | Jae Ang Sim | - |
dc.contributor.author | Ji-Uk Choi | - |
dc.contributor.author | Beom Koo Lee | - |
dc.contributor.author | Hong Gi Park | - |
dc.date.available | 2020-04-06T06:40:42Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1225-1623 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26194 | - |
dc.description.abstract | Purpose: We studied the effect of interleukin-8 (IL-8) as the factor for angiogenesis in the joint fluid of remnantpreserved anterior cruciate ligament reconstruction (RP-ACLR). Materials and methods: We measured 12 cytokines in joint fluid by multiplex assay and assessed the relationship between IL-8 and vascular endothelial growth factor (VEGF) concentrations. The signal intensity and mean sagittal diameter via postoperative magnetic resonance imaging (MRI) scans were evaluated and the stress X-ray image was analyzed at 3, 6, and 12 months after operation. Results: The IL-8 concentration was highest 3 months postoperatively in those patients who underwent RP-ACLR. Clinical data also showed that the signal intensity and stress radiography of the knee graft were significantly better at the early postoperative stage. Discussion: Our results show that IL-8 plays an important role in angiogenesis within 3 months after RP-ACLR. This effect yields better recovery after operation. RP-ACLR patients with high knee stability in clinical data were identical to those with high expression of IL-8 in experimental data. Therefore, IL-8 has been shown to help revascularization and ligamentization of the grafted tendon. These results indicate that IL-8 in RP-ACLR is an important factor for angiogenesis after operation. Unfortunately, the relationship of IL-8 and VEGF in vivo has not been studied. Conclusion: Our results showed that the IL-8 concentration was very high within 3 months after RP-ACLR operation. The increase in concentration of IL-8 over time was consistent with the increase in VEGF concentration. In the IL-8 clinical setting, MRI analysis showed that ACL synovialization and tension were better in patients who underwent the remnant preservation method. In addition, it was shown that RP-ACLR may be advantageous for early anterior stability within 1 year post operation and beneficial for tendon graft in the early stage post operation. Taken together, our findings suggest that IL-8 may contribute to angiogenesis which is helpful for revascularization and ligamentization of the graft tendon in the early stages of RP-ACLR. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한슬관절학회 | - |
dc.relation.isPartOf | Knee Surgery and Related Research | - |
dc.title | The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation | - |
dc.title.alternative | The effect of interleukin-8 in the early stage after anterior cruciate ligament reconstruction with remnant preservation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.wosid | 000705471200006 | - |
dc.identifier.doi | 10.1186/s43019-019-0024-0 | - |
dc.identifier.bibliographicCitation | Knee Surgery and Related Research, v.32, no.1, pp.5 - 5 | - |
dc.identifier.kciid | ART002550216 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85119417480 | - |
dc.citation.endPage | 5 | - |
dc.citation.startPage | 5 | - |
dc.citation.title | Knee Surgery and Related Research | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Kyung-Ok Kim | - |
dc.contributor.affiliatedAuthor | Jae Ang Sim | - |
dc.contributor.affiliatedAuthor | Ji-Uk Choi | - |
dc.contributor.affiliatedAuthor | Beom Koo Lee | - |
dc.contributor.affiliatedAuthor | Hong Gi Park | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Interleukin-8 | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Joint fluid | - |
dc.subject.keywordAuthor | Remnant preservation | - |
dc.subject.keywordAuthor | Anterior cruciate ligament reconstruction | - |
dc.subject.keywordPlus | ANTI-INTERLEUKIN-6 RECEPTOR ANTIBODY | - |
dc.subject.keywordPlus | ACL | - |
dc.subject.keywordPlus | MECHANORECEPTORS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | ARTHRITIS | - |
dc.subject.keywordPlus | GRAFTS | - |
dc.relation.journalResearchArea | Orthopedics | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Orthopedics | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | kci | - |
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