防己茯苓湯이 백서에서 LPS로 유도된 우울증에서 면역 조직학적 변화에 미치는 효과
DC Field | Value | Language |
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dc.contributor.author | 박성준 | - |
dc.contributor.author | 이태희 | - |
dc.date.available | 2020-04-06T06:42:57Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1229-1218 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26297 | - |
dc.description.abstract | Objective : This study is accomplished in order to investigate the effect of banggibongnyeongtang on the immunohistological change in LPS-induced depression rats to confirm the histological result of the previous behavioral and biochemical effect. Methods : LPS 5 ㎍ was injected to lateral ventricle and experimental groups were administered BBT intraperitoneally. The concentration of 5-HT in the Medial Prefrontal Cortex, Striatum, Hippocampus, Amygdala was measured by ELISA. IL-1β, TNF-α mRNA and BDNF mRNA expression in the hippocampus was examined by RT-PCR. Result : BBT enhanced 5-HT concentration at all part of brain but no significantly difference at medial prefrontal cortex and striatum. LPS+BBT400 group increased 5-HT concentration significantly than LPS group at hippocampus and amygdala (p<0.05). BBT decreased IL-1β mRNA expression dose dependently but only with significantly decrease in LPS+BBT400 group than LPS group’s in Hippocampus (p<0.05). But BBT did not decrease TNF-α mRNA expression significantly in Hippocampus. BBT increased the expression of BDNF mRNA at hippocampus and LPS+BBT400 group significantly increased comparing with LPS group does (p<0.05). Conclusion : It is postulated that the anti-depressant effect of BBT can be validated through the anti-inflammatory effect, 5-HT concentration increase, and the neuro-protective effect mediated by BDNF by combining the results of the previous report about the behavioral and biochemical effect. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 대한한의학방제학회 | - |
dc.relation.isPartOf | 대한한의학 방제학회지 | - |
dc.title | 防己茯苓湯이 백서에서 LPS로 유도된 우울증에서 면역 조직학적 변화에 미치는 효과 | - |
dc.title.alternative | Effect of Banggibongnyeongtang on the immunohistological change in LPS-induced depression rats | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 2 | - |
dc.identifier.bibliographicCitation | 대한한의학 방제학회지, v.28, no.1, pp.53 - 62 | - |
dc.identifier.kciid | ART002564125 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 62 | - |
dc.citation.startPage | 53 | - |
dc.citation.title | 대한한의학 방제학회지 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | 박성준 | - |
dc.contributor.affiliatedAuthor | 이태희 | - |
dc.subject.keywordAuthor | banggibongnyeongtang | - |
dc.subject.keywordAuthor | LPS | - |
dc.subject.keywordAuthor | antidepression | - |
dc.subject.keywordAuthor | 5-HT | - |
dc.subject.keywordAuthor | IL-1β | - |
dc.subject.keywordAuthor | TNF-α | - |
dc.subject.keywordAuthor | BDNF | - |
dc.description.journalRegisteredClass | kci | - |
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