Inhibitory effects of orientin in mast cell-mediated allergic inflammation
DC Field | Value | Language |
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dc.contributor.author | Dhakal H. | - |
dc.contributor.author | Lee S. | - |
dc.contributor.author | Choi J.K. | - |
dc.contributor.author | Kwon T.K. | - |
dc.contributor.author | Khang D. | - |
dc.contributor.author | Kim S.-H. | - |
dc.date.available | 2020-04-06T06:43:38Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1734-1140 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26326 | - |
dc.description.abstract | Background: Mast cells are immune effector cells mediating allergic inflammation by the secretion of inflammatory mediators such as histamine and pro-inflammatory cytokines. Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. The objective of this study was to rule out the effectiveness of orientin in mast cell-mediated allergic inflammation. Methods: In this study, in vitro effects of orientin were evaluated in RBL-2H3, mouse bone marrow-derived mast cells, rat peritoneal mast cells, and in vivo effects were evaluated by inducing passive cutaneous anaphylaxis (PCA) in Imprinting Control Region (ICR) mice. Results: Findings show that orientin suppressed the immunoglobulin E (IgE)-mediated mast cell degranulation by reducing intracellular calcium level in a concentration-dependent manner. Orientin suppressed the secretion of pro-inflammatory cytokines in mast cells. This inhibitory effects of orientin was through inhibition of FcεRI-mediated signaling proteins. In addition, oral administration of orientin suppressed the IgE-mediated PCA reactions in a dose-dependent manner, which was evidenced by reduced Evan’s blue pigmentation and ear swelling. Conclusions: Based on these findings, we suggest that orientin might have potential to alleviate allergic reaction and mast cell-mediated allergic disease. © 2020, Maj Institute of Pharmacology Polish Academy of Sciences. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | Pharmacological Reports | - |
dc.title | Inhibitory effects of orientin in mast cell-mediated allergic inflammation | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000523335500001 | - |
dc.identifier.doi | 10.1007/s43440-019-00048-3 | - |
dc.identifier.bibliographicCitation | Pharmacological Reports, v.72, no.4, pp.1002 - 1010 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85079677163 | - |
dc.citation.endPage | 1010 | - |
dc.citation.startPage | 1002 | - |
dc.citation.title | Pharmacological Reports | - |
dc.citation.volume | 72 | - |
dc.citation.number | 4 | - |
dc.contributor.affiliatedAuthor | Khang D. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Allergic inflammation | - |
dc.subject.keywordAuthor | Histamine | - |
dc.subject.keywordAuthor | Mast cell | - |
dc.subject.keywordAuthor | Orientin | - |
dc.subject.keywordAuthor | Passive cutaneous anaphylaxis | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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