Nanoparticle-mediated therapeutic application for modulation of lysosomal ion channels and functions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee D. | - |
dc.contributor.author | Hong J.H. | - |
dc.date.available | 2020-04-06T07:37:14Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1999-4923 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26395 | - |
dc.description.abstract | Applications of nanoparticles in various fields have been addressed. Nanomaterials serve as carriers for transporting conventional drugs or proteins through lysosomes to various cellular targets. The basic function of lysosomes is to trigger degradation of proteins and lipids. Understanding of lysosomal functions is essential for enhancing the efficacy of nanoparticles-mediated therapy and reducing the malfunctions of cellular metabolism. The lysosomal function is modulated by the movement of ions through various ion channels. Thus, in this review, we have focused on the recruited ion channels for lysosomal function, to understand the lysosomal modulation through the nanoparticles and its applications. In the future, lysosomal channels-based targets will expand the therapeutic application of nanoparticles-associated drugs. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | Pharmaceutics | - |
dc.title | Nanoparticle-mediated therapeutic application for modulation of lysosomal ion channels and functions | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000526541000091 | - |
dc.identifier.doi | 10.3390/pharmaceutics12030217 | - |
dc.identifier.bibliographicCitation | Pharmaceutics, v.12, no.3 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85081270773 | - |
dc.citation.title | Pharmaceutics | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Lee D. | - |
dc.contributor.affiliatedAuthor | Hong J.H. | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | Ion channels | - |
dc.subject.keywordAuthor | Lysosome | - |
dc.subject.keywordAuthor | Nanodrugs | - |
dc.subject.keywordAuthor | Nanomaterials | - |
dc.subject.keywordAuthor | Nanoparticles | - |
dc.subject.keywordPlus | calcium channel | - |
dc.subject.keywordPlus | chloride channel | - |
dc.subject.keywordPlus | cystic fibrosis transmembrane conductance regulator | - |
dc.subject.keywordPlus | ion channel | - |
dc.subject.keywordPlus | membrane protein | - |
dc.subject.keywordPlus | nanomaterial | - |
dc.subject.keywordPlus | nanoparticle | - |
dc.subject.keywordPlus | proton | - |
dc.subject.keywordPlus | purinergic P2X4 receptor | - |
dc.subject.keywordPlus | transient receptor potential channel | - |
dc.subject.keywordPlus | transient receptor potential channel M | - |
dc.subject.keywordPlus | transient receptor potential channel M2 | - |
dc.subject.keywordPlus | transmembrane protein 175 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | bioaccumulation | - |
dc.subject.keywordPlus | cell function | - |
dc.subject.keywordPlus | cell invasion | - |
dc.subject.keywordPlus | cell maturation | - |
dc.subject.keywordPlus | cell migration | - |
dc.subject.keywordPlus | cell proliferation | - |
dc.subject.keywordPlus | cell viability | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | lysosome | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | pH | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | Review | - |
dc.subject.keywordPlus | signal transduction | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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