Microwave-assisted modified synthesis of C8-analogues of naturally occurring methylxanthines: Synthesis, biological evaluation and their practical applications
DC Field | Value | Language |
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dc.contributor.author | Shyamlal B.R.K. | - |
dc.contributor.author | Mathur M. | - |
dc.contributor.author | Yadav D.K. | - |
dc.contributor.author | Chaudhary S. | - |
dc.date.available | 2020-04-06T07:38:31Z | - |
dc.date.created | 2020-04-02 | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 0367-326X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/26431 | - |
dc.description.abstract | An efficient, microwave-assisted, oxidant-interceded, transition-metal-free, cross-dehydrogenative Csp 2-Csp 3 coupling of C8-Caffeine 2/Theobromine 3/theophylline 4 with substituted aliphatic alcohols 11a-l via C[sbnd]H bond activation for the preparation of series of substituted C8-(hydroxymethyl) Caffeine 12a-l/theobromine 13a-c/theophylline 14a-b has been developed using microwave irradiation upto 98% yield. The reaction proceeds smoothly in the presence of tert-butyl hydroperoxide (TBHP) under solvolysis condition at 120 °C for 20 min to corresponding substituted C8-(hydroxymethyl)-methylxanthine derivatives in good to excellent yields. The good substrate scope, control experiments, gram-scale synthesis, and practical synthetic transformations further highlights the practicality of this methodology. These C8-(hydroxymethyl) Caffeine 12a-l, 13a-c and 14a-b have been found to show promising in vitro antioxidant as well as antiplatelet activities. © 2020 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isPartOf | Fitoterapia | - |
dc.title | Microwave-assisted modified synthesis of C8-analogues of naturally occurring methylxanthines: Synthesis, biological evaluation and their practical applications | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000532686800002 | - |
dc.identifier.doi | 10.1016/j.fitote.2020.104533 | - |
dc.identifier.bibliographicCitation | Fitoterapia, v.143 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85081682106 | - |
dc.citation.title | Fitoterapia | - |
dc.citation.volume | 143 | - |
dc.contributor.affiliatedAuthor | Yadav D.K. | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Antiplatelet | - |
dc.subject.keywordAuthor | Cross-dehydrogenative coupling (CDC) | - |
dc.subject.keywordAuthor | Double C[sbnd]H bond activation | - |
dc.subject.keywordAuthor | Microwave | - |
dc.subject.keywordAuthor | TBHP | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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